Diehl JA - Search Results

1

Inhibition of the PERK-Dependent Unfolded Protein Response Signaling Pathway Involved in the Pathogenesis of Alzheimer's Disease.

Rozpędek W, Pytel D, Popławski T, Walczak A, Gradzik K, Wawrzynkiewicz A, Wojtczak R, Mucha B, Diehl JA, Majsterek I. Rozpędek W, et al. Among authors: diehl ja. Curr Alzheimer Res. 2019;16(3):209-218. doi: 10.2174/1567205016666190228121157. Curr Alzheimer Res. 2019. PMID: 30819079

2

PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway.

Hamanaka RB, Bennett BS, Cullinan SB, Diehl JA. Hamanaka RB, et al. Among authors: diehl ja. Mol Biol Cell. 2005 Dec;16(12):5493-501. doi: 10.1091/mbc.e05-03-0268. Epub 2005 Sep 21. Mol Biol Cell. 2005. PMID: 16176978 Free PMC article.

3

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage.

Bobrovnikova-Marjon E, Grigoriadou C, Pytel D, Zhang F, Ye J, Koumenis C, Cavener D, Diehl JA. Bobrovnikova-Marjon E, et al. Among authors: diehl ja. Oncogene. 2010 Jul 8;29(27):3881-95. doi: 10.1038/onc.2010.153. Epub 2010 May 10. Oncogene. 2010. PMID: 20453876 Free PMC article.

4

The cell biology of the unfolded protein response.

Diehl JA, Fuchs SY, Koumenis C. Diehl JA, et al. Gastroenterology. 2011 Jul;141(1):38-41, 41.e1-2. doi: 10.1053/j.gastro.2011.05.018. Epub 2011 May 24. Gastroenterology. 2011. PMID: 21620842 Free PMC article. Review.

5

PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation.

Bobrovnikova-Marjon E, Pytel D, Riese MJ, Vaites LP, Singh N, Koretzky GA, Witze ES, Diehl JA. Bobrovnikova-Marjon E, et al. Among authors: diehl ja. Mol Cell Biol. 2012 Jun;32(12):2268-78. doi: 10.1128/MCB.00063-12. Epub 2012 Apr 9. Mol Cell Biol. 2012. PMID: 22493067 Free PMC article.

6

miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner.

Chitnis NS, Pytel D, Bobrovnikova-Marjon E, Pant D, Zheng H, Maas NL, Frederick B, Kushner JA, Chodosh LA, Koumenis C, Fuchs SY, Diehl JA. Chitnis NS, et al. Among authors: diehl ja. Mol Cell. 2012 Nov 9;48(3):353-64. doi: 10.1016/j.molcel.2012.08.025. Epub 2012 Sep 27. Mol Cell. 2012. PMID: 23022383 Free PMC article.

7

UPR-inducible miRNAs contribute to stressful situations.

Chitnis N, Pytel D, Diehl JA. Chitnis N, et al. Among authors: diehl ja. Trends Biochem Sci. 2013 Sep;38(9):447-52. doi: 10.1016/j.tibs.2013.06.012. Epub 2013 Jul 29. Trends Biochem Sci. 2013. PMID: 23906563 Free PMC article. Review.

8

Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors.

Pytel D, Seyb K, Liu M, Ray SS, Concannon J, Huang M, Cuny GD, Diehl JA, Glicksman MA. Pytel D, et al. Among authors: diehl ja. J Biomol Screen. 2014 Aug;19(7):1024-34. doi: 10.1177/1087057114525853. Epub 2014 Mar 5. J Biomol Screen. 2014. PMID: 24598103 Free PMC article.

9

Molecular pathways: the PERKs and pitfalls of targeting the unfolded protein response in cancer.

Maas NL, Diehl JA. Maas NL, et al. Among authors: diehl ja. Clin Cancer Res. 2015 Feb 15;21(4):675-9. doi: 10.1158/1078-0432.CCR-13-3239. Epub 2014 Sep 2. Clin Cancer Res. 2015. PMID: 25182515 Free PMC article. Review.

10

Tumor progression and the different faces of the PERK kinase.

Pytel D, Majsterek I, Diehl JA. Pytel D, et al. Among authors: diehl ja. Oncogene. 2016 Mar 10;35(10):1207-15. doi: 10.1038/onc.2015.178. Epub 2015 Jun 1. Oncogene. 2016. PMID: 26028033 Free PMC article. Review.

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