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Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function.
Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5160-5169. doi: 10.1073/pnas.1816071116. Epub 2019 Feb 22.
Proc Natl Acad Sci U S A. 2019.
PMID: 30796190
Free PMC article.
(R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses.
Zanos P, Highland JN, Liu X, Troppoli TA, Georgiou P, Lovett J, Morris PJ, Stewart BW, Thomas CJ, Thompson SM, Moaddel R, Gould TD.
Zanos P, et al. Among authors: troppoli ta.
Br J Pharmacol. 2019 Jul;176(14):2573-2592. doi: 10.1111/bph.14683. Epub 2019 May 13.
Br J Pharmacol. 2019.
PMID: 30941749
Free PMC article.
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Harnessing psilocybin: antidepressant-like behavioral and synaptic actions of psilocybin are independent of 5-HT2R activation in mice.
Hesselgrave N, Troppoli TA, Wulff AB, Cole AB, Thompson SM.
Hesselgrave N, et al. Among authors: troppoli ta.
Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2022489118. doi: 10.1073/pnas.2022489118.
Proc Natl Acad Sci U S A. 2021.
PMID: 33850049
Free PMC article.
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Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice.
Troppoli TA, Zanos P, Georgiou P, Gould TD, Rudolph U, Thompson SM.
Troppoli TA, et al.
Biol Psychiatry. 2022 Aug 1;92(3):216-226. doi: 10.1016/j.biopsych.2021.11.024. Epub 2021 Dec 15.
Biol Psychiatry. 2022.
PMID: 35120711
Free PMC article.
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Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in the basal forebrain.
Troppoli TA, Yang C, Katsuki F, Uygun DS, Lin I, Aguilar DD, Spratt T, Basheer R, McNally JM, Savio Chan C, McKenna JT, Brown RE.
Troppoli TA, et al.
Proc Natl Acad Sci U S A. 2024 May 21;121(21):e2321410121. doi: 10.1073/pnas.2321410121. Epub 2024 May 15.
Proc Natl Acad Sci U S A. 2024.
PMID: 38748575
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Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in basal forebrain.
Troppoli TA, Yang C, Katsuki F, Uygun DS, Lin I, Aguilar D, Spratt T, Basheer R, McNally JM, Chan CS, McKenna JT, Brown RE.
Troppoli TA, et al.
bioRxiv [Preprint]. 2023 Nov 11:2023.11.09.566065. doi: 10.1101/2023.11.09.566065.
bioRxiv. 2023.
PMID: 37986953
Free PMC article.
Preprint.
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