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529 results

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Antidepressant-relevant concentrations of the ketamine metabolite (2R,6R)-hydroxynorketamine do not block NMDA receptor function.
Lumsden EW, Troppoli TA, Myers SJ, Zanos P, Aracava Y, Kehr J, Lovett J, Kim S, Wang FH, Schmidt S, Jenne CE, Yuan P, Morris PJ, Thomas CJ, Zarate CA Jr, Moaddel R, Traynelis SF, Pereira EFR, Thompson SM, Albuquerque EX, Gould TD. Lumsden EW, et al. Among authors: thomas cj. Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5160-5169. doi: 10.1073/pnas.1816071116. Epub 2019 Feb 22. Proc Natl Acad Sci U S A. 2019. PMID: 30796190 Free PMC article.
Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice.
Neumann S, Huang W, Titus S, Krause G, Kleinau G, Alberobello AT, Zheng W, Southall NT, Inglese J, Austin CP, Celi FS, Gavrilova O, Thomas CJ, Raaka BM, Gershengorn MC. Neumann S, et al. Among authors: thomas cj. Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12471-6. doi: 10.1073/pnas.0904506106. Epub 2009 Jul 10. Proc Natl Acad Sci U S A. 2009. PMID: 19592511 Free PMC article.
Phosphodiesterase 4 inhibitors enhance sexual pleasure-seeking activity in rodents.
Yuan P, Tragon T, Xia M, Leclair CA, Skoumbourdis AP, Zheng W, Thomas CJ, Huang R, Austin CP, Chen G, Guitart X. Yuan P, et al. Among authors: thomas cj. Pharmacol Biochem Behav. 2011 May;98(3):349-55. doi: 10.1016/j.pbb.2011.02.001. Epub 2011 Feb 4. Pharmacol Biochem Behav. 2011. PMID: 21296104 Free PMC article.
Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy.
Law AJ, Wang Y, Sei Y, O'Donnell P, Piantadosi P, Papaleo F, Straub RE, Huang W, Thomas CJ, Vakkalanka R, Besterman AD, Lipska BK, Hyde TM, Harrison PJ, Kleinman JE, Weinberger DR. Law AJ, et al. Among authors: thomas cj. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12165-70. doi: 10.1073/pnas.1206118109. Epub 2012 Jun 11. Proc Natl Acad Sci U S A. 2012. PMID: 22689948 Free PMC article.
High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.
Mathews Griner LA, Guha R, Shinn P, Young RM, Keller JM, Liu D, Goldlust IS, Yasgar A, McKnight C, Boxer MB, Duveau DY, Jiang JK, Michael S, Mierzwa T, Huang W, Walsh MJ, Mott BT, Patel P, Leister W, Maloney DJ, Leclair CA, Rai G, Jadhav A, Peyser BD, Austin CP, Martin SE, Simeonov A, Ferrer M, Staudt LM, Thomas CJ. Mathews Griner LA, et al. Among authors: thomas cj. Proc Natl Acad Sci U S A. 2014 Feb 11;111(6):2349-54. doi: 10.1073/pnas.1311846111. Epub 2014 Jan 27. Proc Natl Acad Sci U S A. 2014. PMID: 24469833 Free PMC article.
NMDAR inhibition-independent antidepressant actions of ketamine metabolites.
Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI, Alkondon M, Yuan P, Pribut HJ, Singh NS, Dossou KS, Fang Y, Huang XP, Mayo CL, Wainer IW, Albuquerque EX, Thompson SM, Thomas CJ, Zarate CA Jr, Gould TD. Zanos P, et al. Among authors: thomas cj. Nature. 2016 May 26;533(7604):481-6. doi: 10.1038/nature17998. Epub 2016 May 4. Nature. 2016. PMID: 27144355 Free PMC article.
Reply to: Antidepressant Actions of Ketamine Versus Hydroxynorketamine.
Zanos P, Moaddel R, Morris PJ, Wainer IW, Albuquerque EX, Thompson SM, Thomas CJ, Zarate CA Jr, Gould TD. Zanos P, et al. Among authors: thomas cj. Biol Psychiatry. 2017 Apr 15;81(8):e69-e71. doi: 10.1016/j.biopsych.2016.08.039. Epub 2016 Sep 30. Biol Psychiatry. 2017. PMID: 27817846 Free PMC article. No abstract available.
Zanos et al. reply.
Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI, Alkondon M, Yuan P, Pribut HJ, Singh NS, Dossou KSS, Fang Y, Huang XP, Mayo CL, Albuquerque EX, Thompson SM, Thomas CJ, Zarate CA, Gould TD. Zanos P, et al. Among authors: thomas cj. Nature. 2017 Jun 21;546(7659):E4-E5. doi: 10.1038/nature22085. Nature. 2017. PMID: 28640272 Free PMC article. No abstract available.
529 results