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HRAS-driven cancer cells are vulnerable to TRPML1 inhibition.
Jung J, Cho KJ, Naji AK, Clemons KN, Wong CO, Villanueva M, Gregory S, Karagas NE, Tan L, Liang H, Rousseau MA, Tomasevich KM, Sikora AG, Levental I, van der Hoeven D, Zhou Y, Hancock JF, Venkatachalam K. Jung J, et al. Among authors: van der hoeven d. EMBO Rep. 2019 Apr;20(4):e46685. doi: 10.15252/embr.201846685. Epub 2019 Feb 20. EMBO Rep. 2019. PMID: 30787043 Free PMC article.
Raf inhibitors target ras spatiotemporal dynamics.
Cho KJ, Kasai RS, Park JH, Chigurupati S, Heidorn SJ, van der Hoeven D, Plowman SJ, Kusumi A, Marais R, Hancock JF. Cho KJ, et al. Among authors: van der hoeven d. Curr Biol. 2012 Jun 5;22(11):945-55. doi: 10.1016/j.cub.2012.03.067. Epub 2012 May 3. Curr Biol. 2012. PMID: 22560614 Free article.
Inhibitors of K-Ras plasma membrane localization.
Cho KJ, van der Hoeven D, Hancock JF. Cho KJ, et al. Among authors: van der hoeven d. Enzymes. 2013;33 Pt A:249-65. doi: 10.1016/B978-0-12-416749-0.00011-7. Epub 2013 Aug 8. Enzymes. 2013. PMID: 25033808 Review.
AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2.
Cho KJ, Casteel DE, Prakash P, Tan L, van der Hoeven D, Salim AA, Kim C, Capon RJ, Lacey E, Cunha SR, Gorfe AA, Hancock JF. Cho KJ, et al. Among authors: van der hoeven d. Mol Cell Biol. 2016 Nov 28;36(24):3086-3099. doi: 10.1128/MCB.00365-16. Print 2016 Dec 15. Mol Cell Biol. 2016. PMID: 27697864 Free PMC article.
Sphingomyelin Metabolism Is a Regulator of K-Ras Function.
van der Hoeven D, Cho KJ, Zhou Y, Ma X, Chen W, Naji A, Montufar-Solis D, Zuo Y, Kovar SE, Levental KR, Frost JA, van der Hoeven R, Hancock JF. van der Hoeven D, et al. Among authors: van der hoeven r. Mol Cell Biol. 2018 Jan 16;38(3):e00373-17. doi: 10.1128/MCB.00373-17. Print 2018 Feb 1. Mol Cell Biol. 2018. PMID: 29158292 Free PMC article.
30 results