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HRAS-driven cancer cells are vulnerable to TRPML1 inhibition.
Jung J, Cho KJ, Naji AK, Clemons KN, Wong CO, Villanueva M, Gregory S, Karagas NE, Tan L, Liang H, Rousseau MA, Tomasevich KM, Sikora AG, Levental I, van der Hoeven D, Zhou Y, Hancock JF, Venkatachalam K. Jung J, et al. Among authors: hancock jf. EMBO Rep. 2019 Apr;20(4):e46685. doi: 10.15252/embr.201846685. Epub 2019 Feb 20. EMBO Rep. 2019. PMID: 30787043 Free PMC article.
Raf inhibitors target ras spatiotemporal dynamics.
Cho KJ, Kasai RS, Park JH, Chigurupati S, Heidorn SJ, van der Hoeven D, Plowman SJ, Kusumi A, Marais R, Hancock JF. Cho KJ, et al. Among authors: hancock jf. Curr Biol. 2012 Jun 5;22(11):945-55. doi: 10.1016/j.cub.2012.03.067. Epub 2012 May 3. Curr Biol. 2012. PMID: 22560614 Free article.
Ras nanoclusters: a new drug target?
Cho KJ, Hancock JF. Cho KJ, et al. Among authors: hancock jf. Small GTPases. 2013 Jan-Mar;4(1):57-60. doi: 10.4161/sgtp.23145. Epub 2013 Jan 1. Small GTPases. 2013. PMID: 23419283 Free PMC article.
221 results