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Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent.
Chou LC, Chen CT, Lee JC, Way TD, Huang CH, Huang SM, Teng CM, Yamori T, Wu TS, Sun CM, Chien DS, Qian K, Morris-Natschke SL, Lee KH, Huang LJ, Kuo SC. Chou LC, et al. Among authors: huang lj, huang sm, huang ch. J Med Chem. 2010 Feb 25;53(4):1616-26. doi: 10.1021/jm901292j. J Med Chem. 2010. PMID: 20102207
The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells.
Huang SM, Yang JS, Tsai SC, Chen MH, Hsu MH, Lin HY, Chou LC, Chinag JH, Lee KH, Huang LJ, Kuo SC. Huang SM, et al. Among authors: huang lj. Int J Oncol. 2011 May;38(5):1357-64. doi: 10.3892/ijo.2011.952. Epub 2011 Feb 22. Int J Oncol. 2011. PMID: 21344160
1,241 results