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Page 1
Discovery of Second Generation RORγ Inhibitors Composed of an Azole Scaffold.
Kotoku M, Maeba T, Fujioka S, Yokota M, Seki N, Ito K, Suwa Y, Ikenogami T, Hirata K, Hase Y, Katsuda Y, Miyagawa N, Arita K, Asahina K, Noguchi M, Nomura A, Doi S, Adachi T, Crowe P, Tao H, Thacher S, Hashimoto H, Suzuki T, Shiozaki M. Kotoku M, et al. Among authors: asahina k. J Med Chem. 2019 Mar 14;62(5):2837-2842. doi: 10.1021/acs.jmedchem.8b01567. Epub 2019 Mar 1. J Med Chem. 2019. PMID: 30776227
SAR Exploration Guided by LE and Fsp(3): Discovery of a Selective and Orally Efficacious RORγ Inhibitor.
Hirata K, Kotoku M, Seki N, Maeba T, Maeda K, Hirashima S, Sakai T, Obika S, Hori A, Hase Y, Yamaguchi T, Katsuda Y, Hata T, Miyagawa N, Arita K, Nomura Y, Asahina K, Aratsu Y, Kamada M, Adachi T, Noguchi M, Doi S, Crowe P, Bradley E, Steensma R, Tao H, Fenn M, Babine R, Li X, Thacher S, Hashimoto H, Shiozaki M. Hirata K, et al. Among authors: asahina k. ACS Med Chem Lett. 2015 Nov 4;7(1):23-7. doi: 10.1021/acsmedchemlett.5b00253. eCollection 2016 Jan 14. ACS Med Chem Lett. 2015. PMID: 26819660 Free PMC article.
Discovery and SAR of JTE-151: A Novel RORγ Inhibitor for Clinical Development.
Maeba T, Hirata K, Kotoku M, Seki N, Maeda K, Hirashima S, Yamanaka H, Sakai T, Obika S, Hori A, Hara Y, Noji S, Suwa Y, Yokota M, Fujioka S, Yamaguchi T, Katsuda Y, Hata T, Miyagawa N, Arita K, Nomura Y, Taniguchi T, Asahina K, Aratsu Y, Naka Y, Adachi T, Nomura A, Akai S, Oshida SI, Pai S, Crowe P, Bradley E, Steensma R, Tao H, Fenn M, Babine R, Li X, Thacher S, Soeta T, Ukaji Y, Shiozaki M. Maeba T, et al. Among authors: asahina k. J Med Chem. 2024 Jan 25;67(2):952-970. doi: 10.1021/acs.jmedchem.3c01933. Epub 2024 Jan 3. J Med Chem. 2024. PMID: 38170624
Role of Pex19p in the targeting of PMP70 to peroxisome.
Kashiwayama Y, Asahina K, Shibata H, Morita M, Muntau AC, Roscher AA, Wanders RJ, Shimozawa N, Sakaguchi M, Kato H, Imanaka T. Kashiwayama Y, et al. Among authors: asahina k. Biochim Biophys Acta. 2005 Dec 15;1746(2):116-28. doi: 10.1016/j.bbamcr.2005.10.006. Epub 2005 Nov 14. Biochim Biophys Acta. 2005. PMID: 16344115 Free article.
Role of NH2-terminal hydrophobic motif in the subcellular localization of ATP-binding cassette protein subfamily D: common features in eukaryotic organisms.
Lee A, Asahina K, Okamoto T, Kawaguchi K, Kostsin DG, Kashiwayama Y, Takanashi K, Yazaki K, Imanaka T, Morita M. Lee A, et al. Among authors: asahina k. Biochem Biophys Res Commun. 2014 Oct 24;453(3):612-8. doi: 10.1016/j.bbrc.2014.09.133. Epub 2014 Oct 6. Biochem Biophys Res Commun. 2014. PMID: 25301552
Interlaboratory evaluation of LC-MS-based biomarker assays.
Saito K, Goda R, Arai K, Asahina K, Kawabata M, Uchiyama H, Andou T, Shimizu H, Takahara K, Kakehi M, Yamauchi S, Nitta SI, Suga T, Fujita H, Ishikawa R, Saito Y. Saito K, et al. Among authors: asahina k. Bioanalysis. 2024 Mar;16(6):389-402. doi: 10.4155/bio-2023-0173. Epub 2024 Feb 9. Bioanalysis. 2024. PMID: 38334082 Review.
Heterozygous midnolin knockout attenuates severity of nonalcoholic fatty liver disease in mice fed a Western-style diet high in fat, cholesterol, and fructose.
Kweon SM, Irimia-Dominguez J, Kim G, Fueger PT, Asahina K, Lai KK, Allende DS, Lai QR, Lou CH, Tsark WM, Yang JD, Ng DS, Lee JS, Tso P, Huang W, Lai KKY. Kweon SM, et al. Among authors: asahina k. Am J Physiol Gastrointest Liver Physiol. 2023 Aug 1;325(2):G147-G157. doi: 10.1152/ajpgi.00011.2023. Epub 2023 May 2. Am J Physiol Gastrointest Liver Physiol. 2023. PMID: 37129245
146 results