Middaugh CR - Search Results

1

A Collection of Single-Domain Antibodies that Crowd Ricin Toxin's Active Site.

Angalakurthi SK, Vance DJ, Rong Y, Nguyen CMT, Rudolph MJ, Volkin D, Middaugh CR, Weis DD, Mantis NJ. Angalakurthi SK, et al. Among authors: middaugh cr. Antibodies (Basel). 2018 Dec;7(4):45. doi: 10.3390/antib7040045. Epub 2018 Dec 17. Antibodies (Basel). 2018. PMID: 30775035 Free PMC article.

2

Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies.

Bazzoli A, Vance DJ, Rudolph MJ, Rong Y, Angalakurthi SK, Toth RT 4th, Middaugh CR, Volkin DB, Weis DD, Karanicolas J, Mantis NJ. Bazzoli A, et al. Among authors: middaugh cr. Proteins. 2017 Nov;85(11):1994-2008. doi: 10.1002/prot.25353. Epub 2017 Aug 4. Proteins. 2017. PMID: 28718923 Free PMC article.

3

High-Resolution Epitope Positioning of a Large Collection of Neutralizing and Nonneutralizing Single-Domain Antibodies on the Enzymatic and Binding Subunits of Ricin Toxin.

Vance DJ, Tremblay JM, Rong Y, Angalakurthi SK, Volkin DB, Middaugh CR, Weis DD, Shoemaker CB, Mantis NJ. Vance DJ, et al. Among authors: middaugh cr. Clin Vaccine Immunol. 2017 Dec 5;24(12):e00236-17. doi: 10.1128/CVI.00236-17. Print 2017 Dec. Clin Vaccine Immunol. 2017. PMID: 29021300 Free PMC article.

4

High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine.

Toth RT 4th, Angalakurthi SK, Van Slyke G, Vance DJ, Hickey JM, Joshi SB, Middaugh CR, Volkin DB, Weis DD, Mantis NJ. Toth RT 4th, et al. Among authors: middaugh cr. Clin Vaccine Immunol. 2017 Dec 5;24(12):e00237-17. doi: 10.1128/CVI.00237-17. Print 2017 Dec. Clin Vaccine Immunol. 2017. PMID: 29046307 Free PMC article.

5

Contribution of an unusual CDR2 element of a single domain antibody in ricin toxin binding affinity and neutralizing activity.

Rudolph MJ, Vance DJ, Kelow S, Angalakurthi SK, Nguyen S, Davis SA, Rong Y, Middaugh CR, Weis DD, Dunbrack R Jr, Karanicolas J, Mantis NJ. Rudolph MJ, et al. Among authors: middaugh cr. Protein Eng Des Sel. 2018 Jul 1;31(7-8):277-287. doi: 10.1093/protein/gzy022. Protein Eng Des Sel. 2018. PMID: 30265352 Free PMC article.

6

Fine-Specificity Epitope Analysis Identifies Contact Points on Ricin Toxin Recognized by Protective Monoclonal Antibodies.

Van Slyke G, Angalakurthi SK, Toth RT 4th, Vance DJ, Rong Y, Ehrbar D, Shi Y, Middaugh CR, Volkin DB, Weis DD, Mantis NJ. Van Slyke G, et al. Among authors: middaugh cr. Immunohorizons. 2018 Sep;2(8):262-273. doi: 10.4049/immunohorizons.1800042. Immunohorizons. 2018. PMID: 30766971 Free PMC article.

7

Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen.

Thomas JC, O'Hara JM, Hu L, Gao FP, Joshi SB, Volkin DB, Brey RN, Fang J, Karanicolas J, Mantis NJ, Middaugh CR. Thomas JC, et al. Among authors: middaugh cr. Hum Vaccin Immunother. 2013 Apr;9(4):744-52. doi: 10.4161/hv.22998. Epub 2013 Apr 1. Hum Vaccin Immunother. 2013. PMID: 23563512 Free PMC article.

8

Hydrogen-deuterium exchange mass spectrometry as an emerging analytical tool for stabilization and formulation development of therapeutic monoclonal antibodies.

Majumdar R, Middaugh CR, Weis DD, Volkin DB. Majumdar R, et al. Among authors: middaugh cr. J Pharm Sci. 2015 Feb;104(2):327-45. doi: 10.1002/jps.24224. Epub 2014 Oct 29. J Pharm Sci. 2015. PMID: 25354868 Review.

9

Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice.

Wahome N, Sully E, Singer C, Thomas JC, Hu L, Joshi SB, Volkin DB, Fang J, Karanicolas J, Jacobs DJ, Mantis NJ, Middaugh CR. Wahome N, et al. Among authors: middaugh cr. J Pharm Sci. 2016 May;105(5):1603-1613. doi: 10.1016/j.xphs.2016.02.009. Epub 2016 Mar 15. J Pharm Sci. 2016. PMID: 26987947 Free PMC article.

10

Correlating excipient effects on conformational and storage stability of an IgG1 monoclonal antibody with local dynamics as measured by hydrogen/deuterium-exchange mass spectrometry.

Manikwar P, Majumdar R, Hickey JM, Thakkar SV, Samra HS, Sathish HA, Bishop SM, Middaugh CR, Weis DD, Volkin DB. Manikwar P, et al. Among authors: middaugh cr. J Pharm Sci. 2013 Jul;102(7):2136-51. doi: 10.1002/jps.23543. Epub 2013 Apr 25. J Pharm Sci. 2013. PMID: 23620222

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