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Page 1
Molecular Modeling and Functional Analysis of Exome Sequencing-Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma.
Egan JB, Marks DL, Hogenson TL, Vrabel AM, Sigafoos AN, Tolosa EJ, Carr RM, Safgren SL, Hesles EE, Almada LL, Romecin-Duran PA, Iguchi E, Ala'Aldeen A, Kocher JA, Oliver GR, Prodduturi N, Mead DW, Hossain A, Huneke NE, Tagtow CM, Ailawadhi S, Ansell SM, Banck MS, Bryce AH, Carballido EM, Chanan-Khan AA, Curtis KK, Resnik E, Gawryletz CD, Go RS, Halfdanarson TR, Ho TH, Joseph RW, Kapoor P, Mansfield AS, Meurice N, Nageswara Rao AA, Nowakowski GS, Pardanani A, Parikh SA, Cheville JC, Feldman AL, Ramanathan RK, Robinson SI, Tibes R, Finnes HD, McCormick JB, McWilliams RR, Jatoi A, Patnaik MM, Silva AC, Wieben ED, McAllister TM, Rumilla KM, Kerr SE, Lazaridis KN, Farrugia G, Stewart AK, Clark KJ, Kennedy EJ, Klee EW, Borad MJ, Fernandez-Zapico ME. Egan JB, et al. Among authors: marks dl. JCO Precis Oncol. 2017;2017:PO.17.00018. doi: 10.1200/PO.17.00018. Epub 2017 Aug 1. JCO Precis Oncol. 2017. PMID: 30761385 Free PMC article.
Epigenetic control of the tumor microenvironment.
Marks DL, Olson RL, Fernandez-Zapico ME. Marks DL, et al. Epigenomics. 2016 Dec;8(12):1671-1687. doi: 10.2217/epi-2016-0110. Epub 2016 Oct 4. Epigenomics. 2016. PMID: 27700179 Free PMC article. Review.
Pancreatic Cancer, A Mis-interpreter of the Epigenetic Language.
Iguchi E, Safgren SL, Marks DL, Olson RL, Fernandez-Zapico ME. Iguchi E, et al. Among authors: marks dl. Yale J Biol Med. 2016 Dec 23;89(4):575-590. eCollection 2016 Dec. Yale J Biol Med. 2016. PMID: 28018146 Free PMC article. Review.
The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner.
Nye MD, Almada LL, Fernandez-Barrena MG, Marks DL, Elsawa SF, Vrabel A, Tolosa EJ, Ellenrieder V, Fernandez-Zapico ME. Nye MD, et al. Among authors: marks dl. J Biol Chem. 2014 May 30;289(22):15495-506. doi: 10.1074/jbc.M113.545194. Epub 2014 Apr 16. J Biol Chem. 2014. PMID: 24739390 Free PMC article.
A rare germline CDKN2A variant (47T>G; p16-L16R) predisposes carriers to pancreatic cancer by reducing cell cycle inhibition.
Horn IP, Marks DL, Koenig AN, Hogenson TL, Almada LL, Goldstein LE, Romecin Duran PA, Vera R, Vrabel AM, Cui G, Rabe KG, Bamlet WR, Mer G, Sicotte H, Zhang C, Li H, Petersen GM, Fernandez-Zapico ME. Horn IP, et al. Among authors: marks dl. J Biol Chem. 2021 Jan-Jun;296:100634. doi: 10.1016/j.jbc.2021.100634. Epub 2021 Apr 3. J Biol Chem. 2021. PMID: 33823155 Free PMC article.
Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer.
McCleary-Wheeler AL, Carr RM, Palmer SR, Smyrk TC, Allred JB, Almada LL, Tolosa EJ, Lamberti MJ, Marks DL, Borad MJ, Molina JR, Qi Y, Lingle WL, Grothey A, Pitot HC, Jatoi A, Northfelt DW, Bryce AH, McWilliams RR, Okuno SH, Haluska P, Kim GP, Colon-Otero G, Lowe VJ, Callstrom MR, Ma WW, Bekaii-Saab T, Hung MC, Erlichman C, Fernandez-Zapico ME. McCleary-Wheeler AL, et al. Among authors: marks dl. Pancreatology. 2020 Jan;20(1):101-109. doi: 10.1016/j.pan.2019.11.011. Epub 2019 Nov 21. Pancreatology. 2020. PMID: 31787526 Free PMC article. Clinical Trial.
TFII-I-mediated polymerase pausing antagonizes GLI2 induction by TGFβ.
McCleary-Wheeler AL, Paradise BD, Almada LL, Carlson AJ, Marks DL, Vrabel A, Vera RE, Sigafoos AN, Olson RL, Fernandez-Zapico ME. McCleary-Wheeler AL, et al. Among authors: marks dl. Nucleic Acids Res. 2020 Jul 27;48(13):7169-7181. doi: 10.1093/nar/gkaa476. Nucleic Acids Res. 2020. PMID: 32544250 Free PMC article.
GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression.
Tolosa EJ, Fernandez-Barrena MG, Iguchi E, McCleary-Wheeler AL, Carr RM, Almada LL, Flores LF, Vera RE, Alfonse GW, Marks DL, Hogenson TL, Vrabel AM, Horn IP, Koenig AN, Safgren SL, Sigafoos AN, Erkan M, Romecin-Duran PA, Sarabia Gonzalez A, Zhou B, Javelaud D, Marsaud V, Graham RP, Mauviel A, Elsawa SF, Fernandez-Zapico ME. Tolosa EJ, et al. Among authors: marks dl. Biochem J. 2020 Sep 18;477(17):3131-3145. doi: 10.1042/BCJ20200335. Biochem J. 2020. PMID: 32766732
302 results