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GPCRomics: An Approach to Discover GPCR Drug Targets.
Insel PA, Sriram K, Gorr MW, Wiley SZ, Michkov A, Salmerón C, Chinn AM. Insel PA, et al. Trends Pharmacol Sci. 2019 Jun;40(6):378-387. doi: 10.1016/j.tips.2019.04.001. Epub 2019 May 8. Trends Pharmacol Sci. 2019. PMID: 31078319 Free PMC article. Review.
G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets.
Insel PA, Wilderman A, Zambon AC, Snead AN, Murray F, Aroonsakool N, McDonald DS, Zhou S, McCann T, Zhang L, Sriram K, Chinn AM, Michkov AV, Lynch RM, Overland AC, Corriden R. Insel PA, et al. Mol Pharmacol. 2015 Jul;88(1):181-7. doi: 10.1124/mol.115.098129. Epub 2015 Mar 3. Mol Pharmacol. 2015. PMID: 25737495 Free PMC article. Review.
Pulmonary artery smooth muscle cells from normal subjects and IPAH patients show divergent cAMP-mediated effects on TRPC expression and capacitative Ca2+ entry.
Zhang S, Patel HH, Murray F, Remillard CV, Schach C, Thistlethwaite PA, Insel PA, Yuan JX. Zhang S, et al. Among authors: insel pa. Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1202-10. doi: 10.1152/ajplung.00214.2006. Epub 2006 Dec 22. Am J Physiol Lung Cell Mol Physiol. 2007. PMID: 17189322 Free article.
The cyclic AMP effector Epac integrates pro- and anti-fibrotic signals.
Yokoyama U, Patel HH, Lai NC, Aroonsakool N, Roth DM, Insel PA. Yokoyama U, et al. Among authors: insel pa. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6386-91. doi: 10.1073/pnas.0801490105. Epub 2008 Apr 23. Proc Natl Acad Sci U S A. 2008. PMID: 18434542 Free PMC article.
437 results