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IL4-10 fusion protein has chondroprotective, anti-inflammatory and potentially analgesic effects in the treatment of osteoarthritis.
Steen-Louws C, Popov-Celeketic J, Mastbergen SC, Coeleveld K, Hack CE, Eijkelkamp N, Tryfonidou M, Spruijt S, van Roon JAG, Lafeber FPJG. Steen-Louws C, et al. Among authors: eijkelkamp n. Osteoarthritis Cartilage. 2018 Aug;26(8):1127-1135. doi: 10.1016/j.joca.2018.05.005. Epub 2018 May 26. Osteoarthritis Cartilage. 2018. PMID: 29775732 Free article.
Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways.
Prado J, Westerink RHS, Popov-Celeketic J, Steen-Louws C, Pandit A, Versteeg S, van de Worp W, Kanters DHAJ, Reedquist KA, Koenderman L, Hack CE, Eijkelkamp N. Prado J, et al. Among authors: eijkelkamp n. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):e2009647118. doi: 10.1073/pnas.2009647118. Proc Natl Acad Sci U S A. 2021. PMID: 33836560 Free PMC article.
IL4-10 Fusion Protein Shows DMOAD Activity in a Rat Osteoarthritis Model.
van Helvoort EM, de Visser HM, Lafeber FPJG, Coeleveld K, Versteeg S, Weinans HH, Popov-Celeketic J, Eijkelkamp N, Mastbergen SC. van Helvoort EM, et al. Among authors: eijkelkamp n. Cartilage. 2021 Dec;13(2_suppl):1155S-1164S. doi: 10.1177/19476035211026736. Epub 2021 Jun 23. Cartilage. 2021. PMID: 34159843 Free PMC article.
Dorsal Root Ganglia Macrophages Maintain Osteoarthritis Pain.
Raoof R, Martin Gil C, Lafeber FPJG, de Visser H, Prado J, Versteeg S, Pascha MN, Heinemans ALP, Adolfs Y, Pasterkamp J, Wood JN, Mastbergen SC, Eijkelkamp N. Raoof R, et al. Among authors: eijkelkamp n. J Neurosci. 2021 Sep 29;41(39):8249-8261. doi: 10.1523/JNEUROSCI.1787-20.2021. Epub 2021 Aug 16. J Neurosci. 2021. PMID: 34400519 Free PMC article.
Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain.
van der Vlist M, Raoof R, Willemen HLDM, Prado J, Versteeg S, Martin Gil C, Vos M, Lokhorst RE, Pasterkamp RJ, Kojima T, Karasuyama H, Khoury-Hanold W, Meyaard L, Eijkelkamp N. van der Vlist M, et al. Among authors: eijkelkamp n. Neuron. 2022 Feb 16;110(4):613-626.e9. doi: 10.1016/j.neuron.2021.11.020. Epub 2021 Dec 17. Neuron. 2022. PMID: 34921782 Free article.
Inflammation-induced mitochondrial and metabolic disturbances in sensory neurons control the switch from acute to chronic pain.
Willemen HLDM, Santos Ribeiro PS, Broeks M, Meijer N, Versteeg S, Tiggeler A, de Boer TP, Małecki JM, Falnes PØ, Jans J, Eijkelkamp N. Willemen HLDM, et al. Among authors: eijkelkamp n. Cell Rep Med. 2023 Nov 21;4(11):101265. doi: 10.1016/j.xcrm.2023.101265. Epub 2023 Nov 8. Cell Rep Med. 2023. PMID: 37944527 Free PMC article.
71 results