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Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant.
de Souza GA, da Silva SJ, Del Cistia CN, Pitasse-Santos P, Pires LO, Passos YM, Cordeiro Y, Cardoso CM, Castro RN, Sant'Anna CMR, Kümmerle AE. de Souza GA, et al. Among authors: cordeiro y. J Enzyme Inhib Med Chem. 2019 Dec;34(1):631-637. doi: 10.1080/14756366.2019.1571270. J Enzyme Inhib Med Chem. 2019. PMID: 30727776 Free PMC article.
Targeting Biomolecular Condensation and Protein Aggregation against Cancer.
Silva JL, Foguel D, Ferreira VF, Vieira TCRG, Marques MA, Ferretti GDS, Outeiro TF, Cordeiro Y, de Oliveira GAP. Silva JL, et al. Among authors: cordeiro y. Chem Rev. 2023 Jul 26;123(14):9094-9138. doi: 10.1021/acs.chemrev.3c00131. Epub 2023 Jun 28. Chem Rev. 2023. PMID: 37379327 Review.
Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands.
Petronilho EC, Pedrote MM, Marques MA, Passos YM, Mota MF, Jakobus B, de Sousa GDS, Pereira da Costa F, Felix AL, Ferretti GDS, Almeida FP, Cordeiro Y, Vieira TCRG, de Oliveira GAP, Silva JL. Petronilho EC, et al. Among authors: cordeiro y. Chem Sci. 2021 Apr 26;12(21):7334-7349. doi: 10.1039/d1sc01739j. Chem Sci. 2021. PMID: 34163823 Free PMC article.
Prion protein complexed to a DNA aptamer induce behavioral and synapse dysfunction in mice.
P B Gomes M, de Lima EV, G Q Barros-Aragão F, Passos YM, Lemos FS, Zamberlan DC, Ribeiro G, Macedo B, C Ferreira N, Silva JL, Figueiredo CP, Clarke JR, Cordeiro Y. P B Gomes M, et al. Among authors: cordeiro y. Behav Brain Res. 2022 Feb 15;419:113680. doi: 10.1016/j.bbr.2021.113680. Epub 2021 Nov 22. Behav Brain Res. 2022. PMID: 34822947
Synthesis and anti-prion activity evaluation of aminoquinoline analogues.
Macedo B, Kaschula CH, Hunter R, Chaves JA, van der Merwe JD, Silva JL, Egan TJ, Cordeiro Y. Macedo B, et al. Among authors: cordeiro y. Eur J Med Chem. 2010 Nov;45(11):5468-73. doi: 10.1016/j.ejmech.2010.07.054. Epub 2010 Aug 6. Eur J Med Chem. 2010. PMID: 20797807
90 results