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Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides.
Wu Y, Kaur A, Fowler E, Wiedmann MM, Young R, Galloway WRJD, Olsen L, Sore HF, Chattopadhyay A, Kwan TT, Xu W, Walsh SJ, de Andrade P, Janecek M, Arumugam S, Itzhaki LS, Lau YH, Spring DR. Wu Y, et al. Among authors: fowler e. ACS Chem Biol. 2019 Mar 15;14(3):526-533. doi: 10.1021/acschembio.9b00063. Epub 2019 Feb 7. ACS Chem Biol. 2019. PMID: 30702850
Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.
Charoenpattarapreeda J, Tan YS, Iegre J, Walsh SJ, Fowler E, Eapen RS, Wu Y, Sore HF, Verma CS, Itzhaki L, Spring DR. Charoenpattarapreeda J, et al. Among authors: fowler e. Chem Commun (Camb). 2019 Jul 14;55(55):7914-7917. doi: 10.1039/c9cc04022f. Epub 2019 Jun 21. Chem Commun (Camb). 2019. PMID: 31225847
Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction.
Strizhak AV, Babii O, Afonin S, Bakanovich I, Pantelejevs T, Xu W, Fowler E, Eapen R, Sharma K, Platonov MO, Hurmach VV, Itzhaki L, Hyvönen M, Ulrich AS, Spring DR, Komarov IV. Strizhak AV, et al. Among authors: fowler e. Org Biomol Chem. 2020 Jul 22;18(28):5359-5369. doi: 10.1039/d0ob00831a. Org Biomol Chem. 2020. PMID: 32390036 Free article.
Site-selective modification strategies in antibody-drug conjugates.
Walsh SJ , Bargh JD , Dannheim FM , Hanby AR , Seki H , Counsell AJ , Ou X , Fowler E , Ashman N , Takada Y , Isidro-Llobet A , Parker JS , Carroll JS , Spring DR . Walsh SJ , et al. Among authors: fowler e. Chem Soc Rev. 2021 Jan 21;50(2):1305-1353. doi: 10.1039/d0cs00310g. Epub 2020 Dec 8. Chem Soc Rev. 2021. PMID: 33290462 Review.
Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion.
Kidd SL, Fowler E, Reinhardt T, Compton T, Mateu N, Newman H, Bellini D, Talon R, McLoughlin J, Krojer T, Aimon A, Bradley A, Fairhead M, Brear P, Díaz-Sáez L, McAuley K, Sore HF, Madin A, O'Donovan DH, Huber KVM, Hyvönen M, von Delft F, Dowson CG, Spring DR. Kidd SL, et al. Among authors: fowler e. Chem Sci. 2020 May 14;11(39):10792-10801. doi: 10.1039/d0sc01232g. Chem Sci. 2020. PMID: 34094333 Free PMC article.
The human proton pump inhibitors inhibit Mycobacterium tuberculosis rifampicin efflux and macrophage-induced rifampicin tolerance.
Lake MA, Adams KN, Nie F, Fowler E, Verma AK, Dei S, Teodori E, Sherman DR, Edelstein PH, Spring DR, Troll M, Ramakrishnan L. Lake MA, et al. Among authors: fowler e. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2215512120. doi: 10.1073/pnas.2215512120. Epub 2023 Feb 10. Proc Natl Acad Sci U S A. 2023. PMID: 36763530 Free PMC article.
659 results