Wu H - Search Results

1

SERPINB1-mediated checkpoint of inflammatory caspase activation.

Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU. Choi YJ, et al. Among authors: wu h. Nat Immunol. 2019 Mar;20(3):276-287. doi: 10.1038/s41590-018-0303-z. Epub 2019 Jan 28. Nat Immunol. 2019. PMID: 30692621 Free PMC article.

2

Molecular mechanism for p202-mediated specific inhibition of AIM2 inflammasome activation.

Yin Q, Sester DP, Tian Y, Hsiao YS, Lu A, Cridland JA, Sagulenko V, Thygesen SJ, Choubey D, Hornung V, Walz T, Stacey KJ, Wu H. Yin Q, et al. Among authors: wu h. Cell Rep. 2013 Jul 25;4(2):327-39. doi: 10.1016/j.celrep.2013.06.024. Epub 2013 Jul 11. Cell Rep. 2013. PMID: 23850291 Free PMC article.

3

Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions.

Lu A, Kabaleeswaran V, Fu T, Magupalli VG, Wu H. Lu A, et al. Among authors: wu h. J Mol Biol. 2014 Apr 3;426(7):1420-7. doi: 10.1016/j.jmb.2013.12.029. Epub 2014 Jan 7. J Mol Biol. 2014. PMID: 24406744 Free PMC article.

4

Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes.

Lu A, Magupalli VG, Ruan J, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitzgerald KA, Wu H, Egelman EH. Lu A, et al. Among authors: wu h. Cell. 2014 Mar 13;156(6):1193-1206. doi: 10.1016/j.cell.2014.02.008. Cell. 2014. PMID: 24630722 Free PMC article.

5

Structural mechanisms of inflammasome assembly.

Lu A, Wu H. Lu A, et al. Among authors: wu h. FEBS J. 2015 Feb;282(3):435-44. doi: 10.1111/febs.13133. Epub 2014 Nov 21. FEBS J. 2015. PMID: 25354325 Free PMC article. Review.

6

The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis.

Onizawa M, Oshima S, Schulze-Topphoff U, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A. Onizawa M, et al. Among authors: wu h. Nat Immunol. 2015 Jun;16(6):618-27. doi: 10.1038/ni.3172. Epub 2015 May 4. Nat Immunol. 2015. PMID: 25939025 Free PMC article.

7

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization.

Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y, Wu H. Zhang L, et al. Among authors: wu h, wu j. Science. 2015 Oct 23;350(6259):404-9. doi: 10.1126/science.aac5789. Epub 2015 Oct 8. Science. 2015. PMID: 26449474 Free PMC article.

8

The Inflammasome Adaptor ASC Induces Procaspase-8 Death Effector Domain Filaments.

Vajjhala PR, Lu A, Brown DL, Pang SW, Sagulenko V, Sester DP, Cridland SO, Hill JM, Schroder K, Stow JL, Wu H, Stacey KJ. Vajjhala PR, et al. Among authors: wu h. J Biol Chem. 2015 Dec 4;290(49):29217-30. doi: 10.1074/jbc.M115.687731. Epub 2015 Oct 14. J Biol Chem. 2015. PMID: 26468282 Free PMC article.

9

Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2.

Lu A, Li Y, Yin Q, Ruan J, Yu X, Egelman E, Wu H. Lu A, et al. Among authors: wu h. Cell Discov. 2015;1:15013-. doi: 10.1038/celldisc.2015.13. Epub 2015 Jun 23. Cell Discov. 2015. PMID: 26583071 Free PMC article.

10

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism.

Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H. Lu A, et al. Among authors: wu h. Nat Struct Mol Biol. 2016 May;23(5):416-25. doi: 10.1038/nsmb.3199. Epub 2016 Apr 4. Nat Struct Mol Biol. 2016. PMID: 27043298 Free PMC article.

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