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Phenotypic correction and long-term expression of factor VIII in hemophilic mice by immunotolerization and nonviral gene transfer using the Sleeping Beauty transposon system.
Ohlfest JR, Frandsen JL, Fritz S, Lobitz PD, Perkinson SG, Clark KJ, Nelsestuen G, Key NS, McIvor RS, Hackett PB, Largaespada DA. Ohlfest JR, et al. Among authors: largaespada da. Blood. 2005 Apr 1;105(7):2691-8. doi: 10.1182/blood-2004-09-3496. Epub 2004 Dec 2. Blood. 2005. PMID: 15576475 Free article.
Combinatorial antiangiogenic gene therapy by nonviral gene transfer using the sleeping beauty transposon causes tumor regression and improves survival in mice bearing intracranial human glioblastoma.
Ohlfest JR, Demorest ZL, Motooka Y, Vengco I, Oh S, Chen E, Scappaticci FA, Saplis RJ, Ekker SC, Low WC, Freese AB, Largaespada DA. Ohlfest JR, et al. Among authors: largaespada da. Mol Ther. 2005 Nov;12(5):778-88. doi: 10.1016/j.ymthe.2005.07.689. Epub 2005 Sep 16. Mol Ther. 2005. PMID: 16150649 Free article.
De novo induction of genetically engineered brain tumors in mice using plasmid DNA.
Wiesner SM, Decker SA, Larson JD, Ericson K, Forster C, Gallardo JL, Long C, Demorest ZL, Zamora EA, Low WC, SantaCruz K, Largaespada DA, Ohlfest JR. Wiesner SM, et al. Among authors: largaespada da. Cancer Res. 2009 Jan 15;69(2):431-9. doi: 10.1158/0008-5472.CAN-08-1800. Cancer Res. 2009. PMID: 19147555 Free PMC article.
PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.
Keng VW, Rahrmann EP, Watson AL, Tschida BR, Moertel CL, Jessen WJ, Rizvi TA, Collins MH, Ratner N, Largaespada DA. Keng VW, et al. Among authors: largaespada da. Cancer Res. 2012 Jul 1;72(13):3405-13. doi: 10.1158/0008-5472.CAN-11-4092. Epub 2012 Jun 14. Cancer Res. 2012. PMID: 22700876 Free PMC article.
237 results