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Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin.
Toepfer CN, Wakimoto H, Garfinkel AC, McDonough B, Liao D, Jiang J, Tai AC, Gorham JM, Lunde IG, Lun M, Lynch TL 4th, McNamara JW, Sadayappan S, Redwood CS, Watkins HC, Seidman JG, Seidman CE. Toepfer CN, et al. Among authors: mcnamara jw. Sci Transl Med. 2019 Jan 23;11(476):eaat1199. doi: 10.1126/scitranslmed.aat1199. Sci Transl Med. 2019. PMID: 30674652 Free PMC article.
Probenecid Improves Cardiac Function in Patients With Heart Failure With Reduced Ejection Fraction In Vivo and Cardiomyocyte Calcium Sensitivity In Vitro.
Robbins N, Gilbert M, Kumar M, McNamara JW, Daly P, Koch SE, Conway G, Effat M, Woo JG, Sadayappan S, Rubinstein J. Robbins N, et al. Among authors: mcnamara jw. J Am Heart Assoc. 2018 Jan 13;7(2):e007148. doi: 10.1161/JAHA.117.007148. J Am Heart Assoc. 2018. PMID: 29331959 Free PMC article. Clinical Trial.
Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury.
Barefield DY, McNamara JW, Lynch TL, Kuster DWD, Govindan S, Haar L, Wang Y, Taylor EN, Lorenz JN, Nieman ML, Zhu G, Luther PK, Varró A, Dobrev D, Ai X, Janssen PML, Kass DA, Jones WK, Gilbert RJ, Sadayappan S. Barefield DY, et al. Among authors: mcnamara jw. J Mol Cell Cardiol. 2019 Apr;129:236-246. doi: 10.1016/j.yjmcc.2019.03.006. Epub 2019 Mar 9. J Mol Cell Cardiol. 2019. PMID: 30862451 Free PMC article.
Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systems.
Li A, Nelson SR, Rahmanseresht S, Braet F, Cornachione AS, Previs SB, O'Leary TS, McNamara JW, Rassier DE, Sadayappan S, Previs MJ, Warshaw DM. Li A, et al. Among authors: mcnamara jw. Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21882-21892. doi: 10.1073/pnas.1910549116. Epub 2019 Oct 7. Proc Natl Acad Sci U S A. 2019. PMID: 31591218 Free PMC article.
28 results