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The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.
Horton JL, Davidson MT, Kurishima C, Vega RB, Powers JC, Matsuura TR, Petucci C, Lewandowski ED, Crawford PA, Muoio DM, Recchia FA, Kelly DP. Horton JL, et al. Among authors: lewandowski ed. JCI Insight. 2019 Feb 21;4(4):e124079. doi: 10.1172/jci.insight.124079. eCollection 2019 Feb 21. JCI Insight. 2019. PMID: 30668551 Free PMC article.
The Failing Heart Relies on Ketone Bodies as a Fuel.
Aubert G, Martin OJ, Horton JL, Lai L, Vega RB, Leone TC, Koves T, Gardell SJ, Krüger M, Hoppel CL, Lewandowski ED, Crawford PA, Muoio DM, Kelly DP. Aubert G, et al. Among authors: lewandowski ed. Circulation. 2016 Feb 23;133(8):698-705. doi: 10.1161/CIRCULATIONAHA.115.017355. Epub 2016 Jan 27. Circulation. 2016. PMID: 26819376 Free PMC article.
Mitochondrial pyruvate carriers are required for myocardial stress adaptation.
Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED. Zhang Y, et al. Among authors: lewandowski ed. Nat Metab. 2020 Nov;2(11):1248-1264. doi: 10.1038/s42255-020-00288-1. Epub 2020 Oct 26. Nat Metab. 2020. PMID: 33106689 Free PMC article.
Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop.
Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW II, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, Levy D, Lewandowski ED, McClung JM, Mochly-Rosen D, O'Brien KD, O'Rourke B, Park JY, Ping P, Sack MN, Sheu SS, Shi Y, Shiva S, Wallace DC, Weiss RG, Vernon HJ, Wong R, Schwartz Longacre L. Tian R, et al. Among authors: lewandowski ed. Circulation. 2019 Oct 1;140(14):1205-1216. doi: 10.1161/CIRCULATIONAHA.119.040551. Circulation. 2019. PMID: 31769940 Free PMC article. Review.
Publisher Correction: Mitochondrial pyruvate carriers are required for myocardial stress adaptation.
Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED. Zhang Y, et al. Among authors: lewandowski ed. Nat Metab. 2020 Dec;2(12):1498. doi: 10.1038/s42255-020-00322-2. Nat Metab. 2020. PMID: 33208925 No abstract available.
Short-Chain Fatty Acids Outpace Ketone Oxidation in the Failing Heart.
Carley AN, Maurya SK, Fasano M, Wang Y, Selzman CH, Drakos SG, Lewandowski ED. Carley AN, et al. Among authors: lewandowski ed. Circulation. 2021 May 4;143(18):1797-1808. doi: 10.1161/CIRCULATIONAHA.120.052671. Epub 2021 Feb 19. Circulation. 2021. PMID: 33601938 Free PMC article.
Triacylglycerol turnover in the failing heart.
Carley AN, Lewandowski ED. Carley AN, et al. Among authors: lewandowski ed. Biochim Biophys Acta. 2016 Oct;1861(10):1492-9. doi: 10.1016/j.bbalip.2016.03.012. Epub 2016 Mar 16. Biochim Biophys Acta. 2016. PMID: 26993578 Review.
The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.
Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP. Lehman JJ, et al. Among authors: lewandowski ed. Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. doi: 10.1152/ajpheart.00081.2008. Epub 2008 May 16. Am J Physiol Heart Circ Physiol. 2008. PMID: 18487436 Free PMC article.
84 results