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An online resource for GPCR structure determination and analysis.
Munk C, Mutt E, Isberg V, Nikolajsen LF, Bibbe JM, Flock T, Hanson MA, Stevens RC, Deupi X, Gloriam DE. Munk C, et al. Among authors: flock t. Nat Methods. 2019 Feb;16(2):151-162. doi: 10.1038/s41592-018-0302-x. Epub 2019 Jan 21. Nat Methods. 2019. PMID: 30664776 Free PMC article. Review.
Selectivity determinants of GPCR-G-protein binding.
Flock T, Hauser AS, Lund N, Gloriam DE, Balaji S, Babu MM. Flock T, et al. Nature. 2017 May 18;545(7654):317-322. doi: 10.1038/nature22070. Epub 2017 May 10. Nature. 2017. PMID: 28489817 Free PMC article.
Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation.
Mayer D, Damberger FF, Samarasimhareddy M, Feldmueller M, Vuckovic Z, Flock T, Bauer B, Mutt E, Zosel F, Allain FHT, Standfuss J, Schertler GFX, Deupi X, Sommer ME, Hurevich M, Friedler A, Veprintsev DB. Mayer D, et al. Among authors: flock t. Nat Commun. 2019 Mar 19;10(1):1261. doi: 10.1038/s41467-019-09204-y. Nat Commun. 2019. PMID: 30890705 Free PMC article.
Universal allosteric mechanism for Gα activation by GPCRs.
Flock T, Ravarani CNJ, Sun D, Venkatakrishnan AJ, Kayikci M, Tate CG, Veprintsev DB, Babu MM. Flock T, et al. Nature. 2015 Aug 13;524(7564):173-179. doi: 10.1038/nature14663. Epub 2015 Jul 6. Nature. 2015. PMID: 26147082 Free PMC article.
Probing Gαi1 protein activation at single-amino acid resolution.
Sun D, Flock T, Deupi X, Maeda S, Matkovic M, Mendieta S, Mayer D, Dawson R, Schertler GFX, Madan Babu M, Veprintsev DB. Sun D, et al. Among authors: flock t. Nat Struct Mol Biol. 2015 Sep;22(9):686-694. doi: 10.1038/nsmb.3070. Epub 2015 Aug 10. Nat Struct Mol Biol. 2015. PMID: 26258638 Free PMC article.
28 results