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Synthesis, Biological Evaluation and Structure-Activity Relationships of Diflapolin Analogues as Dual sEH/FLAP Inhibitors.
Vieider L, Romp E, Temml V, Fischer J, Kretzer C, Schoenthaler M, Taha A, Hernández-Olmos V, Sturm S, Schuster D, Werz O, Garscha U, Matuszczak B. Vieider L, et al. Among authors: fischer j. ACS Med Chem Lett. 2018 Nov 29;10(1):62-66. doi: 10.1021/acsmedchemlett.8b00415. eCollection 2019 Jan 10. ACS Med Chem Lett. 2018. PMID: 30655948 Free PMC article.
5-Lipoxygenase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane association and disrupt product formation.
Gerstmeier J, Newcomer ME, Dennhardt S, Romp E, Fischer J, Werz O, Garscha U. Gerstmeier J, et al. Among authors: fischer j. FASEB J. 2016 May;30(5):1892-900. doi: 10.1096/fj.201500210R. Epub 2016 Feb 3. FASEB J. 2016. PMID: 26842853 Free PMC article.
Together, the data suggest that the concealed FY cork impacts membrane association and that FLAP may help shield an uncapped active site.-Gerstmeier, J., Newcomer, M. E., Dennhardt, S., Romp, E., Fischer, J., Werz, O., Garscha, U. 5-Lipoxygenase-activating pr …
Together, the data suggest that the concealed FY cork impacts membrane association and that FLAP may help shield an uncapped active site.-Ge …
Finding New Molecular Targets of Familiar Natural Products Using In Silico Target Prediction.
Mayr F, Möller G, Garscha U, Fischer J, Rodríguez Castaño P, Inderbinen SG, Temml V, Waltenberger B, Schwaiger S, Hartmann RW, Gege C, Martens S, Odermatt A, Pandey AV, Werz O, Adamski J, Stuppner H, Schuster D. Mayr F, et al. Among authors: fischer j. Int J Mol Sci. 2020 Sep 26;21(19):7102. doi: 10.3390/ijms21197102. Int J Mol Sci. 2020. PMID: 32993084 Free PMC article.
12-Oxo-10-glutathionyl-5,8,14-eicosatrienoic acid (TOG10), a novel glutathione-containing eicosanoid generated via the 12-lipoxygenase pathway in human platelets.
Liening S, Fischer J, Jagusch H, Pohnert G, Höcker O, Neusüß C, Werz O, Scriba GKE, Garscha U. Liening S, et al. Among authors: fischer j. Prostaglandins Other Lipid Mediat. 2021 Feb;152:106480. doi: 10.1016/j.prostaglandins.2020.106480. Epub 2020 Oct 22. Prostaglandins Other Lipid Mediat. 2021. PMID: 33172790
Impact of food polyphenols on oxylipin biosynthesis in human neutrophils.
Hartung NM, Fischer J, Ostermann AI, Willenberg I, Rund KM, Schebb NH, Garscha U. Hartung NM, et al. Among authors: fischer j. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1536-1544. doi: 10.1016/j.bbalip.2019.05.002. Epub 2019 May 21. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 31125704
5,879 results