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PYK2/FAK inhibitors reverse hypoxia-induced drug resistance in multiple myeloma.
Muz B, Buggio M, Azab F, de la Puente P, Fiala M, Padval MV, Weaver DT, Pachter JA, Vij R, Azab AK. Muz B, et al. Among authors: pachter ja. Haematologica. 2019 Jul;104(7):e310-e313. doi: 10.3324/haematol.2018.194688. Epub 2019 Jan 17. Haematologica. 2019. PMID: 30655367 Free PMC article. No abstract available.
Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship.
Shapiro IM, Kolev VN, Vidal CM, Kadariya Y, Ring JE, Wright Q, Weaver DT, Menges C, Padval M, McClatchey AI, Xu Q, Testa JR, Pachter JA. Shapiro IM, et al. Among authors: pachter ja. Sci Transl Med. 2014 May 21;6(237):237ra68. doi: 10.1126/scitranslmed.3008639. Sci Transl Med. 2014. PMID: 24848258 Free PMC article.
PI3K/mTOR dual inhibitor VS-5584 preferentially targets cancer stem cells.
Kolev VN, Wright QG, Vidal CM, Ring JE, Shapiro IM, Ricono J, Weaver DT, Padval MV, Pachter JA, Xu Q. Kolev VN, et al. Among authors: pachter ja. Cancer Res. 2015 Jan 15;75(2):446-55. doi: 10.1158/0008-5472.CAN-14-1223. Epub 2014 Nov 28. Cancer Res. 2015. PMID: 25432176
Targeting PYK2 mediates microenvironment-specific cell death in multiple myeloma.
Meads MB, Fang B, Mathews L, Gemmer J, Nong L, Rosado-Lopez I, Nguyen T, Ring JE, Matsui W, MacLeod AR, Pachter JA, Hazlehurst LA, Koomen JM, Shain KH. Meads MB, et al. Among authors: pachter ja. Oncogene. 2016 May;35(21):2723-34. doi: 10.1038/onc.2015.334. Epub 2015 Sep 21. Oncogene. 2016. PMID: 26387544 Free PMC article.
Synergism of FAK and tyrosine kinase inhibition in Ph+ B-ALL.
Churchman ML, Evans K, Richmond J, Robbins A, Jones L, Shapiro IM, Pachter JA, Weaver DT, Houghton PJ, Smith MA, Lock RB, Mullighan CG. Churchman ML, et al. Among authors: pachter ja. JCI Insight. 2016;1(4):e86082. doi: 10.1172/jci.insight.86082. Epub 2016 Apr 7. JCI Insight. 2016. PMID: 27123491 Free PMC article.
Focal Adhesion Kinase as a Potential Target in AML and MDS.
Carter BZ, Mak PY, Wang X, Yang H, Garcia-Manero G, Mak DH, Mu H, Ruvolo VR, Qiu Y, Coombes K, Zhang N, Ragon B, Weaver DT, Pachter JA, Kornblau S, Andreeff M. Carter BZ, et al. Among authors: pachter ja. Mol Cancer Ther. 2017 Jun;16(6):1133-1144. doi: 10.1158/1535-7163.MCT-16-0719. Epub 2017 Mar 7. Mol Cancer Ther. 2017. PMID: 28270436 Free PMC article.
The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma.
Begum A, Ewachiw T, Jung C, Huang A, Norberg KJ, Marchionni L, McMillan R, Penchev V, Rajeshkumar NV, Maitra A, Wood L, Wang C, Wolfgang C, DeJesus-Acosta A, Laheru D, Shapiro IM, Padval M, Pachter JA, Weaver DT, Rasheed ZA, Matsui W. Begum A, et al. Among authors: pachter ja. PLoS One. 2017 Jul 10;12(7):e0180181. doi: 10.1371/journal.pone.0180181. eCollection 2017. PLoS One. 2017. PMID: 28692661 Free PMC article.
Inhibition of FAK kinase activity preferentially targets cancer stem cells.
Kolev VN, Tam WF, Wright QG, McDermott SP, Vidal CM, Shapiro IM, Xu Q, Wicha MS, Pachter JA, Weaver DT. Kolev VN, et al. Among authors: pachter ja. Oncotarget. 2017 Jun 16;8(31):51733-51747. doi: 10.18632/oncotarget.18517. eCollection 2017 Aug 1. Oncotarget. 2017. PMID: 28881682 Free PMC article.
Maintenance Defactinib Versus Placebo After First-Line Chemotherapy in Patients With Merlin-Stratified Pleural Mesothelioma: COMMAND-A Double-Blind, Randomized, Phase II Study.
Fennell DA, Baas P, Taylor P, Nowak AK, Gilligan D, Nakano T, Pachter JA, Weaver DT, Scherpereel A, Pavlakis N, van Meerbeeck JP, Cedrés S, Nolan L, Kindler H, Aerts JGJV. Fennell DA, et al. Among authors: pachter ja. J Clin Oncol. 2019 Apr 1;37(10):790-798. doi: 10.1200/JCO.2018.79.0543. Epub 2019 Feb 20. J Clin Oncol. 2019. PMID: 30785827 Clinical Trial.
81 results