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The triacylglycerol, hydroxytriolein, inhibits triple negative mammary breast cancer cell proliferation through a mechanism dependent on dihydroceramide and Akt.
Guardiola-Serrano F, Beteta-Göbel R, Rodríguez-Lorca R, Ibarguren M, López DJ, Terés S, Alonso-Sande M, Higuera M, Torres M, Busquets X, Escribá PV. Guardiola-Serrano F, et al. Among authors: busquets x. Oncotarget. 2019 Apr 2;10(26):2486-2507. doi: 10.18632/oncotarget.26824. eCollection 2019 Apr 2. Oncotarget. 2019. PMID: 31069012 Free PMC article.
2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy.
Terés S, Lladó V, Higuera M, Barceló-Coblijn G, Martin ML, Noguera-Salvà MA, Marcilla-Etxenike A, García-Verdugo JM, Soriano-Navarro M, Saus C, Gómez-Pinedo U, Busquets X, Escribá PV. Terés S, et al. Among authors: busquets x. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8489-94. doi: 10.1073/pnas.1118349109. Epub 2012 May 14. Proc Natl Acad Sci U S A. 2012. PMID: 22586083 Free PMC article.
Normalization of sphingomyelin levels by 2-hydroxyoleic acid induces autophagic cell death of SF767 cancer cells.
Terés S, Lladó V, Higuera M, Barceló-Coblijn G, Martin ML, Noguera-Salvà MA, Marcilla-Etxenike A, García-Verdugo JM, Soriano-Navarro M, Saus C, Gómez-Pinedo U, Busquets X, Escribá PV. Terés S, et al. Among authors: busquets x. Autophagy. 2012 Oct;8(10):1542-4. doi: 10.4161/auto.21341. Epub 2012 Aug 15. Autophagy. 2012. PMID: 22892762 Free PMC article.
The Novel Anticancer Drug Hydroxytriolein Inhibits Lung Cancer Cell Proliferation via a Protein Kinase Cα- and Extracellular Signal-Regulated Kinase 1/2-Dependent Mechanism.
Guardiola-Serrano F, Beteta-Göbel R, Rodríguez-Lorca R, Ibarguren M, López DJ, Terés S, Alvarez R, Alonso-Sande M, Busquets X, Escribá PV. Guardiola-Serrano F, et al. Among authors: busquets x. J Pharmacol Exp Ther. 2015 Aug;354(2):213-24. doi: 10.1124/jpet.114.222281. Epub 2015 Jun 11. J Pharmacol Exp Ther. 2015. PMID: 26065701
78 results