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Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.
Infante P, Mori M, Alfonsi R, Ghirga F, Aiello F, Toscano S, Ingallina C, Siler M, Cucchi D, Po A, Miele E, D'Amico D, Canettieri G, De Smaele E, Ferretti E, Screpanti I, Uccello Barretta G, Botta M, Botta B, Gulino A, Di Marcotullio L. Infante P, et al. EMBO J. 2015 Jan 13;34(2):200-17. doi: 10.15252/embj.201489213. Epub 2014 Dec 4. EMBO J. 2015. PMID: 25476449 Free PMC article.
Targeting GLI factors to inhibit the Hedgehog pathway.
Infante P, Alfonsi R, Botta B, Mori M, Di Marcotullio L. Infante P, et al. Trends Pharmacol Sci. 2015 Aug;36(8):547-58. doi: 10.1016/j.tips.2015.05.006. Epub 2015 Jun 10. Trends Pharmacol Sci. 2015. PMID: 26072120 Review.
β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells.
Miele E, Po A, Begalli F, Antonucci L, Mastronuzzi A, Marras CE, Carai A, Cucchi D, Abballe L, Besharat ZM, Catanzaro G, Infante P, Di Marcotullio L, Canettieri G, De Smaele E, Screpanti I, Locatelli F, Ferretti E. Miele E, et al. Among authors: infante p. BMC Cancer. 2017 Jul 17;17(1):488. doi: 10.1186/s12885-017-3477-0. BMC Cancer. 2017. PMID: 28716052 Free PMC article.
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61.
Calcaterra A, Iovine V, Botta B, Quaglio D, D'Acquarica I, Ciogli A, Iazzetti A, Alfonsi R, Lospinoso Severini L, Infante P, Di Marcotullio L, Mori M, Ghirga F. Calcaterra A, et al. Among authors: infante p. J Enzyme Inhib Med Chem. 2018 Dec;33(1):349-358. doi: 10.1080/14756366.2017.1419221. J Enzyme Inhib Med Chem. 2018. PMID: 29338454 Free PMC article.
162 results