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Small Multitarget Molecules Incorporating the Enone Moiety.
Liargkova T, Eleftheriadis N, Dekker F, Voulgari E, Avgoustakis C, Sagnou M, Mavroidi B, Pelecanou M, Hadjipavlou-Litina D. Liargkova T, et al. Among authors: dekker f. Molecules. 2019 Jan 7;24(1):199. doi: 10.3390/molecules24010199. Molecules. 2019. PMID: 30621100 Free PMC article.
Activity-Based Probes for 15-Lipoxygenase-1.
Eleftheriadis N, Thee SA, Zwinderman MR, Leus NG, Dekker FJ. Eleftheriadis N, et al. Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12300-5. doi: 10.1002/anie.201606876. Epub 2016 Sep 9. Angew Chem Int Ed Engl. 2016. PMID: 27612308 Free PMC article.
HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice.
Leus NG, van den Bosch T, van der Wouden PE, Krist K, Ourailidou ME, Eleftheriadis N, Kistemaker LE, Bos S, Gjaltema RA, Mekonnen SA, Bischoff R, Gosens R, Haisma HJ, Dekker FJ. Leus NG, et al. Among authors: dekker fj. Sci Rep. 2017 Mar 27;7:45047. doi: 10.1038/srep45047. Sci Rep. 2017. PMID: 28344354 Free PMC article.
The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor.
Wapenaar H, van den Bosch T, Leus NGJ, van der Wouden PE, Eleftheriadis N, Hermans J, Hailu GS, Rotili D, Mai A, Dömling A, Bischoff R, Haisma HJ, Dekker FJ. Wapenaar H, et al. Eur J Med Chem. 2017 Aug 18;136:480-486. doi: 10.1016/j.ejmech.2017.05.015. Epub 2017 May 5. Eur J Med Chem. 2017. PMID: 28527406 Free PMC article.
Discovery of chromenes as inhibitors of macrophage migration inhibitory factor.
Kok T, Wapenaar H, Wang K, Neochoritis CG, Zarganes-Tzitzikas T, Proietti G, Eleftheriadis N, Kurpiewska K, Kalinowska-Tłuścik J, Cool RH, Poelarends GJ, Dömling A, Dekker FJ. Kok T, et al. Bioorg Med Chem. 2018 Mar 1;26(5):999-1005. doi: 10.1016/j.bmc.2017.12.032. Epub 2017 Dec 24. Bioorg Med Chem. 2018. PMID: 29428527 Free PMC article.
724 results