McWilliams JC - Search Results

1

Deprotection of N-Boc Groups under Continuous-Flow High-Temperature Conditions.

Li B, Li R, Dorff P, McWilliams JC, Guinn RM, Guinness SM, Han L, Wang K, Yu S. Li B, et al. Among authors: mcwilliams jc. J Org Chem. 2019 Apr 19;84(8):4846-4855. doi: 10.1021/acs.joc.8b02909. Epub 2019 Jan 18. J Org Chem. 2019. PMID: 30620880

2

Stereoelectronic Effects in Ligand Design: Enantioselective Rhodium-Catalyzed Hydrogenation of Aliphatic Cyclic Tetrasubstituted Enamides and Concise Synthesis of (R)-Tofacitinib.

Li C, Wan F, Chen Y, Peng H, Tang W, Yu S, McWilliams JC, Mustakis J, Samp L, Maguire RJ. Li C, et al. Among authors: mcwilliams jc. Angew Chem Int Ed Engl. 2019 Sep 16;58(38):13573-13583. doi: 10.1002/anie.201908089. Epub 2019 Aug 13. Angew Chem Int Ed Engl. 2019. PMID: 31343811 Review.

3

Practical and Science-Based Strategy for Establishing Acceptable Intakes for Drug Product N-Nitrosamine Impurities.

Dobo KL, Kenyon MO, Dirat O, Engel M, Fleetwood A, Martin M, Mattano S, Musso A, McWilliams JC, Papanikolaou A, Parris P, Whritenour J, Yu S, Kalgutkar AS. Dobo KL, et al. Among authors: mcwilliams jc. Chem Res Toxicol. 2022 Mar 21;35(3):475-489. doi: 10.1021/acs.chemrestox.1c00369. Epub 2022 Feb 25. Chem Res Toxicol. 2022. PMID: 35212515 Free PMC article.

4

S_NAr Regioselectivity Predictions: Machine Learning Triggering DFT Reaction Modeling through Statistical Threshold.

Guan Y, Lee T, Wang K, Yu S, McWilliams JC. Guan Y, et al. Among authors: mcwilliams jc. J Chem Inf Model. 2023 Jun 26;63(12):3751-3760. doi: 10.1021/acs.jcim.3c00580. Epub 2023 Jun 5. J Chem Inf Model. 2023. PMID: 37272922

5

Asymmetric synthesis of vabicaserin via oxidative multicomponent annulation and asymmetric hydrogenation of a 3,4-substituted quinolinium salt.

Dragan V, McWilliams JC, Miller R, Sutherland K, Dillon JL, O'Brien MK. Dragan V, et al. Among authors: mcwilliams jc. Org Lett. 2013 Jun 21;15(12):2942-5. doi: 10.1021/ol401029k. Epub 2013 Jun 10. Org Lett. 2013. PMID: 23751116

6

Early chemical development at Legacy Wyeth Research.

O'Brien MK, Kolb M, Connolly TJ, McWilliams JC, Sutherland K. O'Brien MK, et al. Among authors: mcwilliams jc. Drug Discov Today. 2011 Jan;16(1-2):81-8. doi: 10.1016/j.drudis.2010.11.008. Epub 2010 Nov 25. Drug Discov Today. 2011. PMID: 21111844 Review.

7

Enantioselective hydrogenation of N-H imines.

Hou G, Gosselin F, Li W, McWilliams JC, Sun Y, Weisel M, O'Shea PD, Chen CY, Davies IW, Zhang X. Hou G, et al. Among authors: mcwilliams jc. J Am Chem Soc. 2009 Jul 29;131(29):9882-3. doi: 10.1021/ja903319r. J Am Chem Soc. 2009. PMID: 19569686

8

Catalytic enantioselective hydrogenation of N-alkoxycarbonyl hydrazones: a practical synthesis of chiral hydrazines.

Yoshikawa N, Tan L, McWilliams JC, Ramasamy D, Sheppard R. Yoshikawa N, et al. Among authors: mcwilliams jc. Org Lett. 2010 Jan 15;12(2):276-9. doi: 10.1021/ol902602c. Org Lett. 2010. PMID: 20017501

9

Highly enantioselective hydrogenation of aromatic-heteroaromatic ketones.

Chen CY, Reamer RA, Chilenski JR, McWilliams JC. Chen CY, et al. Among authors: mcwilliams jc. Org Lett. 2003 Dec 25;5(26):5039-42. doi: 10.1021/ol0360795. Org Lett. 2003. PMID: 14682759

10

Enantioselective nitrile anion cyclization to substituted pyrrolidines. A highly efficient synthesis of (3S,4R)-N-tert-butyl-4-arylpyrrolidine-3-carboxylic acid.

Chung JY, Cvetovich R, Amato J, McWilliams JC, Reamer R, DiMichele L. Chung JY, et al. Among authors: mcwilliams jc. J Org Chem. 2005 Apr 29;70(9):3592-601. doi: 10.1021/jo050178+. J Org Chem. 2005. PMID: 15844996

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