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Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles.
List EO, Berryman DE, Funk K, Jara A, Kelder B, Wang F, Stout MB, Zhi X, Sun L, White TA, LeBrasseur NK, Pirtskhalava T, Tchkonia T, Jensen EA, Zhang W, Masternak MM, Kirkland JL, Miller RA, Bartke A, Kopchick JJ. List EO, et al. Among authors: kirkland jl. Endocrinology. 2014 May;155(5):1793-805. doi: 10.1210/en.2013-2086. Epub 2014 Feb 11. Endocrinology. 2014. PMID: 24517230 Free PMC article.
Deleted in Breast Cancer 1 regulates cellular senescence during obesity.
Escande C, Nin V, Pirtskhalava T, Chini CC, Thereza Barbosa M, Mathison A, Urrutia R, Tchkonia T, Kirkland JL, Chini EN. Escande C, et al. Among authors: kirkland jl. Aging Cell. 2014 Oct;13(5):951-3. doi: 10.1111/acel.12235. Epub 2014 Jul 3. Aging Cell. 2014. PMID: 24992635 Free PMC article.
Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.
Stout MB, Tchkonia T, Pirtskhalava T, Palmer AK, List EO, Berryman DE, Lubbers ER, Escande C, Spong A, Masternak MM, Oberg AL, LeBrasseur NK, Miller RA, Kopchick JJ, Bartke A, Kirkland JL. Stout MB, et al. Among authors: kirkland jl. Aging (Albany NY). 2014 Jul;6(7):575-86. doi: 10.18632/aging.100681. Aging (Albany NY). 2014. PMID: 25063774 Free PMC article.
TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess.
Idrissova L, Malhi H, Werneburg NW, LeBrasseur NK, Bronk SF, Fingas C, Tchkonia T, Pirtskhalava T, White TA, Stout MB, Hirsova P, Krishnan A, Liedtke C, Trautwein C, Finnberg N, El-Deiry WS, Kirkland JL, Gores GJ. Idrissova L, et al. Among authors: kirkland jl. J Hepatol. 2015 May;62(5):1156-63. doi: 10.1016/j.jhep.2014.11.033. Epub 2014 Nov 28. J Hepatol. 2015. PMID: 25445398 Free PMC article.
353 results