Osborn RR - Search Results

1

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent.

Kerns JK, Busch-Petersen J, Fu W, Boehm JC, Nie H, Muratore M, Bullion A, Lin G, Li H, Davis R, Lin X, Lakdawala AS, Cousins R, Field R, Payne J, Miller DD, Bamborough P, Christopher JA, Baldwin I, Osborn RR, Yonchuk J, Webb E, Rumsey WL. Kerns JK, et al. Among authors: osborn rr. ACS Med Chem Lett. 2018 Oct 30;9(12):1164-1169. doi: 10.1021/acsmedchemlett.8b00291. eCollection 2018 Dec 13. ACS Med Chem Lett. 2018. PMID: 30613320 Free PMC article.

2

4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy.

Liddle J, Bamborough P, Barker MD, Campos S, Chung CW, Cousins RP, Faulder P, Heathcote ML, Hobbs H, Holmes DS, Ioannou C, Ramirez-Molina C, Morse MA, Osborn R, Payne JJ, Pritchard JM, Rumsey WL, Tape DT, Vicentini G, Whitworth C, Williamson RA. Liddle J, et al. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5222-6. doi: 10.1016/j.bmcl.2012.06.065. Epub 2012 Jun 26. Bioorg Med Chem Lett. 2012. PMID: 22801646

3

Effects of airborne toxicants on pulmonary function and mitochondrial DNA damage in rodent lungs.

Rumsey WL, Bolognese B, Davis AB, Flamberg PL, Foley JP, Katchur SR, Kotzer CJ, Osborn RR, Podolin PL. Rumsey WL, et al. Among authors: osborn rr. Mutagenesis. 2017 May 1;32(3):343-353. doi: 10.1093/mutage/gew063. Mutagenesis. 2017. PMID: 27993944

4

1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma.

Christensen SB, Guider A, Forster CJ, Gleason JG, Bender PE, Karpinski JM, DeWolf WE Jr, Barnette MS, Underwood DC, Griswold DE, Cieslinski LB, Burman M, Bochnowicz S, Osborn RR, Manning CD, Grous M, Hillegas LM, Bartus JO, Ryan MD, Eggleston DS, Haltiwanger RC, Torphy TJ. Christensen SB, et al. Among authors: osborn rr. J Med Chem. 1998 Mar 12;41(6):821-35. doi: 10.1021/jm970090r. J Med Chem. 1998. PMID: 9526558

5

SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence.

Underwood DC, Osborn RR, Kotzer CJ, Adams JL, Lee JC, Webb EF, Carpenter DC, Bochnowicz S, Thomas HC, Hay DW, Griswold DE. Underwood DC, et al. Among authors: osborn rr. J Pharmacol Exp Ther. 2000 Apr;293(1):281-8. J Pharmacol Exp Ther. 2000. PMID: 10734180

6

SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung.

Underwood DC, Osborn RR, Bochnowicz S, Webb EF, Rieman DJ, Lee JC, Romanic AM, Adams JL, Hay DW, Griswold DE. Underwood DC, et al. Among authors: osborn rr. Am J Physiol Lung Cell Mol Physiol. 2000 Nov;279(5):L895-902. doi: 10.1152/ajplung.2000.279.5.L895. Am J Physiol Lung Cell Mol Physiol. 2000. PMID: 11053025 Free article.

7

Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig.

Underwood DC, Bochnowicz S, Osborn RR, Kotzer CJ, Luttmann MA, Hay DW, Gorycki PD, Christensen SB, Torphy TJ. Underwood DC, et al. Among authors: osborn rr. J Pharmacol Exp Ther. 1998 Dec;287(3):988-95. J Pharmacol Exp Ther. 1998. PMID: 9864284

8

Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs.

Underwood DC, Kotzer CJ, Bochnowicz S, Osborn RR, Luttmann MA, Hay DW, Torphy TJ. Underwood DC, et al. Among authors: osborn rr. J Pharmacol Exp Ther. 1994 Jul;270(1):250-9. J Pharmacol Exp Ther. 1994. PMID: 8035322

9

Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram.

Underwood DC, Osborn RR, Novak LB, Matthews JK, Newsholme SJ, Undem BJ, Hand JM, Torphy TJ. Underwood DC, et al. Among authors: osborn rr. J Pharmacol Exp Ther. 1993 Jul;266(1):306-13. J Pharmacol Exp Ther. 1993. PMID: 8392555

10

Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody.

Underwood DC, Osborn RR, Newsholme SJ, Torphy TJ, Hay DW. Underwood DC, et al. Among authors: osborn rr. Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 1):850-7. doi: 10.1164/ajrccm.154.4.8887574. Am J Respir Crit Care Med. 1996. PMID: 8887574

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