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First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers.
Pitchford LM, Rathmacher JA, Fuller JC Jr, Daniels JS, Morrison RD, Akers WS, Abumrad NN, Amarnath V, Currey PM, Roberts LJ, Oates JA, Boutaud O. Pitchford LM, et al. Among authors: daniels js. BMC Pharmacol Toxicol. 2019 Jan 5;20(1):1. doi: 10.1186/s40360-018-0281-7. BMC Pharmacol Toxicol. 2019. PMID: 30611293 Free PMC article. Clinical Trial.
In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate.
Fuller JC Jr, Pitchford LM, Morrison RD, Daniels JS, Flynn CR, Abumrad NN, Oates JA, Boutaud O, Rathmacher JA. Fuller JC Jr, et al. Among authors: daniels js. Food Chem Toxicol. 2018 Nov;121:541-548. doi: 10.1016/j.fct.2018.09.047. Epub 2018 Sep 22. Food Chem Toxicol. 2018. PMID: 30253245 Free PMC article.
VU0810464, a non-urea G protein-gated inwardly rectifying K+ (Kir 3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir 3 channels and reduces stress-induced hyperthermia in mice.
Vo BN, Abney KK, Anderson A, Marron Fernandez de Velasco E, Benneyworth MA, Daniels JS, Morrison RD, Hopkins CR, Weaver CD, Wickman K. Vo BN, et al. Among authors: daniels js. Br J Pharmacol. 2019 Jul;176(13):2238-2249. doi: 10.1111/bph.14671. Epub 2019 May 30. Br J Pharmacol. 2019. PMID: 30924523 Free PMC article.
Medication Exposure in Highly Adherent Psychiatry Patients.
Sutherland JJ, Daly TM, Jacobs K, Khawam EA, Pozuelo L, Morrison RD, Milne SB, Daniels JS, Ryan TP. Sutherland JJ, et al. Among authors: daniels js. ACS Chem Neurosci. 2018 Mar 21;9(3):555-562. doi: 10.1021/acschemneuro.7b00375. Epub 2017 Dec 1. ACS Chem Neurosci. 2018. PMID: 29155555
199 results