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211 results

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RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients.
Venken K, Jacques P, Mortier C, Labadia ME, Decruy T, Coudenys J, Hoyt K, Wayne AL, Hughes R, Turner M, Van Gassen S, Martens L, Smith D, Harcken C, Wahle J, Wang CT, Verheugen E, Schryvers N, Varkas G, Cypers H, Wittoek R, Piette Y, Gyselbrecht L, Van Calenbergh S, Van den Bosch F, Saeys Y, Nabozny G, Elewaut D. Venken K, et al. Among authors: van den bosch f, van gassen s, van calenbergh s. Nat Commun. 2019 Jan 2;10(1):9. doi: 10.1038/s41467-018-07911-6. Nat Commun. 2019. PMID: 30602780 Free PMC article.
A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner.
Coppieters K, Van Beneden K, Jacques P, Dewint P, Vervloet A, Vander Cruyssen B, Van Calenbergh S, Chen G, Franck RW, Verbruggen G, Deforce D, Matthys P, Tsuji M, Rottiers P, Elewaut D. Coppieters K, et al. Among authors: van beneden k, van calenbergh s. J Immunol. 2007 Aug 15;179(4):2300-9. doi: 10.4049/jimmunol.179.4.2300. J Immunol. 2007. PMID: 17675491
A plant-derived ligand favoring monomeric glucocorticoid receptor conformation with impaired transactivation potential attenuates collagen-induced arthritis.
Dewint P, Gossye V, De Bosscher K, Vanden Berghe W, Van Beneden K, Deforce D, Van Calenbergh S, Müller-Ladner U, Vander Cruyssen B, Verbruggen G, Haegeman G, Elewaut D. Dewint P, et al. Among authors: van beneden k, van calenbergh s. J Immunol. 2008 Feb 15;180(4):2608-15. doi: 10.4049/jimmunol.180.4.2608. J Immunol. 2008. PMID: 18250472
Synthesis and in vitro evaluation of alpha-GalCer epimers.
Trappeniers M, Goormans S, Van Beneden K, Decruy T, Linclau B, Al-Shamkhani A, Elliott T, Ottensmeier C, Werner JM, Elewaut D, Van Calenbergh S. Trappeniers M, et al. Among authors: van beneden k, van calenbergh s. ChemMedChem. 2008 Jul;3(7):1061-70. doi: 10.1002/cmdc.200800021. ChemMedChem. 2008. PMID: 18418814
Synthesis and in vivo evaluation of 4-deoxy-4,4-difluoro-KRN7000.
Leung L, Tomassi C, Van Beneden K, Decruy T, Elewaut D, Elliott T, Al-Shamkhani A, Ottensmeier C, Van Calenbergh S, Werner J, Williams T, Linclau B. Leung L, et al. Among authors: van beneden k, van calenbergh s. Org Lett. 2008 Oct 16;10(20):4433-6. doi: 10.1021/ol801663m. Epub 2008 Sep 18. Org Lett. 2008. PMID: 18798635
The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000.
Leung L, Tomassi C, Van Beneden K, Decruy T, Trappeniers M, Elewaut D, Gao Y, Elliott T, Al-Shamkhani A, Ottensmeier C, Werner JM, Williams A, Van Calenbergh S, Linclau B. Leung L, et al. Among authors: van beneden k, van calenbergh s. ChemMedChem. 2009 Mar;4(3):329-34. doi: 10.1002/cmdc.200800348. ChemMedChem. 2009. PMID: 19137519
Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis.
Aspeslagh S, Li Y, Yu ED, Pauwels N, Trappeniers M, Girardi E, Decruy T, Van Beneden K, Venken K, Drennan M, Leybaert L, Wang J, Franck RW, Van Calenbergh S, Zajonc DM, Elewaut D. Aspeslagh S, et al. Among authors: van beneden k, van calenbergh s. EMBO J. 2011 Jun 1;30(11):2294-305. doi: 10.1038/emboj.2011.145. Epub 2011 May 6. EMBO J. 2011. PMID: 21552205 Free PMC article.
211 results