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RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients.
Venken K, Jacques P, Mortier C, Labadia ME, Decruy T, Coudenys J, Hoyt K, Wayne AL, Hughes R, Turner M, Van Gassen S, Martens L, Smith D, Harcken C, Wahle J, Wang CT, Verheugen E, Schryvers N, Varkas G, Cypers H, Wittoek R, Piette Y, Gyselbrecht L, Van Calenbergh S, Van den Bosch F, Saeys Y, Nabozny G, Elewaut D. Venken K, et al. Among authors: elewaut d. Nat Commun. 2019 Jan 2;10(1):9. doi: 10.1038/s41467-018-07911-6. Nat Commun. 2019. PMID: 30602780 Free PMC article.
NKT cells: manipulable managers of joint inflammation.
Coppieters K, Dewint P, Van Beneden K, Jacques P, Seeuws S, Verbruggen G, Deforce D, Elewaut D. Coppieters K, et al. Among authors: elewaut d. Rheumatology (Oxford). 2007 Apr;46(4):565-71. doi: 10.1093/rheumatology/kel437. Epub 2007 Feb 16. Rheumatology (Oxford). 2007. PMID: 17307755 Review.
Osteochondral repair in synovial joints.
Verbruggen G, Wittoek R, Groeneboer S, Cruyssen BV, Goemaere S, Elewaut D. Verbruggen G, et al. Among authors: elewaut d. Curr Opin Rheumatol. 2007 May;19(3):265-71. doi: 10.1097/BOR.0b013e3280be58ff. Curr Opin Rheumatol. 2007. PMID: 17414953 Review.
A single early activation of invariant NK T cells confers long-term protection against collagen-induced arthritis in a ligand-specific manner.
Coppieters K, Van Beneden K, Jacques P, Dewint P, Vervloet A, Vander Cruyssen B, Van Calenbergh S, Chen G, Franck RW, Verbruggen G, Deforce D, Matthys P, Tsuji M, Rottiers P, Elewaut D. Coppieters K, et al. Among authors: elewaut d. J Immunol. 2007 Aug 15;179(4):2300-9. doi: 10.4049/jimmunol.179.4.2300. J Immunol. 2007. PMID: 17675491
355 results