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RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients.
Venken K, Jacques P, Mortier C, Labadia ME, Decruy T, Coudenys J, Hoyt K, Wayne AL, Hughes R, Turner M, Van Gassen S, Martens L, Smith D, Harcken C, Wahle J, Wang CT, Verheugen E, Schryvers N, Varkas G, Cypers H, Wittoek R, Piette Y, Gyselbrecht L, Van Calenbergh S, Van den Bosch F, Saeys Y, Nabozny G, Elewaut D. Venken K, et al. Among authors: cypers h. Nat Commun. 2019 Jan 2;10(1):9. doi: 10.1038/s41467-018-07911-6. Nat Commun. 2019. PMID: 30602780 Free PMC article.
Peripheral manifestations are major determinants of disease phenotype and outcome in new onset spondyloarthritis.
De Craemer AS, Renson T, Deroo L, Van Praet L, Cypers H, Varkas G, Joos R, Devinck M, Gyselbrecht L, Peene I, Thevissen K, Costantino F, D'Agostino MA, Lenaerts J, Carron P, Van den Bosch F, Elewaut D. De Craemer AS, et al. Among authors: cypers h. Rheumatology (Oxford). 2022 Aug 3;61(8):3279-3288. doi: 10.1093/rheumatology/keab887. Rheumatology (Oxford). 2022. PMID: 34850859
Degree of bone marrow oedema in sacroiliac joints of patients with axial spondyloarthritis is linked to gut inflammation and male sex: results from the GIANT cohort.
Van Praet L, Jans L, Carron P, Jacques P, Glorieus E, Colman R, Cypers H, Mielants H, De Vos M, Cuvelier C, Van den Bosch F, Elewaut D. Van Praet L, et al. Among authors: cypers h. Ann Rheum Dis. 2014 Jun;73(6):1186-9. doi: 10.1136/annrheumdis-2013-203854. Epub 2013 Nov 25. Ann Rheum Dis. 2014. PMID: 24276368
Brief Report: Six-Week Treatment of Axial Spondyloarthritis Patients With an Optimal Dose of Nonsteroidal Antiinflammatory Drugs: Early Response to Treatment in Signal Intensity on Magnetic Resonance Imaging of the Sacroiliac Joints.
Varkas G, Jans L, Cypers H, Van Praet L, Carron P, Elewaut D, Van den Bosch F. Varkas G, et al. Among authors: cypers h. Arthritis Rheumatol. 2016 Mar;68(3):672-8. doi: 10.1002/art.39474. Arthritis Rheumatol. 2016. PMID: 26473982
Association of Inflammatory Bowel Disease and Acute Anterior Uveitis, but Not Psoriasis, With Disease Duration in Patients With Axial Spondyloarthritis: Results From Two Belgian Nationwide Axial Spondyloarthritis Cohorts.
Varkas G, Vastesaeger N, Cypers H, Colman R, Renson T, Praet LV, Carron P, Raeman F, Devinck M, Gyselbrecht L, Corluy L, Piette Y, Lenaerts J, Thevissen K, Vanneuville B, Bosch FVD, Elewaut D. Varkas G, et al. Among authors: cypers h. Arthritis Rheumatol. 2018 Oct;70(10):1588-1596. doi: 10.1002/art.40551. Arthritis Rheumatol. 2018. PMID: 29740978
Elevated calprotectin levels reveal bowel inflammation in spondyloarthritis.
Cypers H, Varkas G, Beeckman S, Debusschere K, Vogl T, Roth J, Drennan MB, Lavric M, Foell D, Cuvelier CA, De Vos M, Delanghe J, Van den Bosch F, Elewaut D. Cypers H, et al. Ann Rheum Dis. 2016 Jul;75(7):1357-62. doi: 10.1136/annrheumdis-2015-208025. Epub 2015 Dec 23. Ann Rheum Dis. 2016. PMID: 26698844 Free PMC article.
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