Cytotoxicity of Clostridium difficile toxins A and B requires an active and functional SREBP-2 pathway.
Papatheodorou P, Song S, López-Ureña D, Witte A, Marques F, Ost GS, Schorch B, Chaves-Olarte E, Aktories K.
Papatheodorou P, et al.
FASEB J. 2019 Apr;33(4):4883-4892. doi: 10.1096/fj.201801440R. Epub 2018 Dec 28.
FASEB J. 2019.
PMID: 30592645
Taken together, these findings allowed us to identify the SREBP-2 pathway as a suitable target for the development of antitoxin therapeutics against C. difficile toxins A and B.-Papatheodorou, P., Song, S., Lopez-Urena, D., Witte, A., Marques, F., Ost, G. ...
Taken together, these findings allowed us to identify the SREBP-2 pathway as a suitable target for the development of antitoxin therapeutics …