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Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium.
Summer R, Shaghaghi H, Schriner D, Roque W, Sales D, Cuevas-Mora K, Desai V, Bhushan A, Ramirez MI, Romero F. Summer R, et al. Among authors: shaghaghi h. Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1049-L1060. doi: 10.1152/ajplung.00244.2018. Epub 2019 Mar 20. Am J Physiol Lung Cell Mol Physiol. 2019. PMID: 30892080 Free PMC article.
The FDA-Approved Anthelmintic Pyrvinium Pamoate Inhibits Pancreatic Cancer Cells in Nutrient-Depleted Conditions by Targeting the Mitochondria.
Schultz CW, McCarthy GA, Nerwal T, Nevler A, DuHadaway JB, McCoy MD, Jiang W, Brown SZ, Goetz A, Jain A, Calvert VS, Vishwakarma V, Wang D, Preet R, Cassel J, Summer R, Shaghaghi H, Pommier Y, Baechler SA, Pishvaian MJ, Golan T, Yeo CJ, Petricoin EF, Prendergast GC, Salvino J, Singh PK, Dixon DA, Brody JR. Schultz CW, et al. Among authors: shaghaghi h. Mol Cancer Ther. 2021 Nov;20(11):2166-2176. doi: 10.1158/1535-7163.MCT-20-0652. Epub 2021 Aug 19. Mol Cancer Ther. 2021. PMID: 34413127 Free PMC article.
A model of the aged lung epithelium in idiopathic pulmonary fibrosis.
Shaghaghi H, Cuevas-Mora K, Para R, Tran C, Roque W, Robertson MJ, Rosas IO, Summer R, Romero F. Shaghaghi H, et al. Aging (Albany NY). 2021 Jul 8;13(13):16922-16937. doi: 10.18632/aging.203291. Epub 2021 Jul 8. Aging (Albany NY). 2021. PMID: 34238764 Free PMC article.
25 results