Efremov DG - Search Results

1

Inhibition of thioredoxin-dependent H₂O₂ removal sensitizes malignant B-cells to pharmacological ascorbate.

Graczyk-Jarzynka A, Goral A, Muchowicz A, Zagozdzon R, Winiarska M, Bajor M, Trzeciecka A, Fidyt K, Krupka JA, Cyran J, Szczygiel K, Efremov DG, Gobessi S, Jagielski A, Siudakowska K, Bobrowicz M, Klopotowska M, Barankiewicz J, Malenda A, Lech-Maranda E, Miazek-Zapala N, Skarzynski PH, Domagala A, Golab J, Firczuk M. Graczyk-Jarzynka A, et al. Among authors: efremov dg. Redox Biol. 2019 Feb;21:101062. doi: 10.1016/j.redox.2018.11.020. Epub 2018 Nov 29. Redox Biol. 2019. PMID: 30576925 Free PMC article.

2

ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells.

Gobessi S, Laurenti L, Longo PG, Sica S, Leone G, Efremov DG. Gobessi S, et al. Among authors: efremov dg. Blood. 2007 Mar 1;109(5):2032-9. doi: 10.1182/blood-2006-03-011759. Epub 2006 Oct 12. Blood. 2007. PMID: 17038529 Free article.

3

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells.

Longo PG, Laurenti L, Gobessi S, Sica S, Leone G, Efremov DG. Longo PG, et al. Among authors: efremov dg. Blood. 2008 Jan 15;111(2):846-55. doi: 10.1182/blood-2007-05-089037. Epub 2007 Oct 10. Blood. 2008. PMID: 17928528 Free article.

4

Signaling pathways activated by antigen-receptor engagement in chronic lymphocytic leukemia B-cells.

Efremov DG, Gobessi S, Longo PG. Efremov DG, et al. Autoimmun Rev. 2007 Dec;7(2):102-8. doi: 10.1016/j.autrev.2007.02.021. Epub 2007 Mar 28. Autoimmun Rev. 2007. PMID: 18035318 Review.

5

Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells.

Gobessi S, Laurenti L, Longo PG, Carsetti L, Berno V, Sica S, Leone G, Efremov DG. Gobessi S, et al. Among authors: efremov dg. Leukemia. 2009 Apr;23(4):686-97. doi: 10.1038/leu.2008.346. Epub 2008 Dec 18. Leukemia. 2009. PMID: 19092849

6

Synovial B cells of rheumatoid arthritis express ZAP-70 which increases the survival and correlates with the inflammatory and autoimmune phenotype.

Tolusso B, De Santis M, Bosello S, Gremese E, Gobessi S, Cuoghi I, Totaro MC, Bigotti G, Rumi C, Efremov DG, Ferraccioli G. Tolusso B, et al. Among authors: efremov dg. Clin Immunol. 2009 Apr;131(1):98-108. doi: 10.1016/j.clim.2008.11.011. Epub 2009 Jan 12. Clin Immunol. 2009. PMID: 19136305

7

Phosphorylation of the activation loop tyrosines is required for sustained Syk signaling and growth factor-independent B-cell proliferation.

Carsetti L, Laurenti L, Gobessi S, Longo PG, Leone G, Efremov DG. Carsetti L, et al. Among authors: efremov dg. Cell Signal. 2009 Jul;21(7):1187-94. doi: 10.1016/j.cellsig.2009.03.007. Epub 2009 Mar 16. Cell Signal. 2009. PMID: 19296913

8

The Aurora A and B kinases are up-regulated in bone marrow-derived chronic lymphocytic leukemia cells and represent potential therapeutic targets.

de Paula Careta F, Gobessi S, Panepucci RA, Bojnik E, Morato de Oliveira F, Mazza Matos D, Falcão RP, Laurenti L, Zago MA, Efremov DG. de Paula Careta F, et al. Among authors: efremov dg. Haematologica. 2012 Aug;97(8):1246-54. doi: 10.3324/haematol.2011.054668. Epub 2012 Feb 13. Haematologica. 2012. PMID: 22331265 Free PMC article.

9

Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT.

Negro R, Gobessi S, Longo PG, He Y, Zhang ZY, Laurenti L, Efremov DG. Negro R, et al. Among authors: efremov dg. Blood. 2012 Jun 28;119(26):6278-87. doi: 10.1182/blood-2012-01-403162. Epub 2012 May 8. Blood. 2012. PMID: 22569400 Free PMC article.

10

TLR9 signaling defines distinct prognostic subsets in CLL.

Efremov DG, Bomben R, Gobessi S, Gattei V. Efremov DG, et al. Front Biosci (Landmark Ed). 2013 Jan 1;18(1):371-86. doi: 10.2741/4108. Front Biosci (Landmark Ed). 2013. PMID: 23276930 Free article. Review.

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