Howard KA - Search Results

1

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis.

Garcia JP, Stein J, Cai Y, Riemers F, Wexselblatt E, Wengel J, Tryfonidou M, Yayon A, Howard KA, Creemers LB. Garcia JP, et al. Among authors: howard ka. J Control Release. 2019 Jan 28;294:247-258. doi: 10.1016/j.jconrel.2018.12.030. Epub 2018 Dec 18. J Control Release. 2019. PMID: 30572032 Free article.

2

The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice.

Gao S, Dagnaes-Hansen F, Nielsen EJ, Wengel J, Besenbacher F, Howard KA, Kjems J. Gao S, et al. Among authors: howard ka. Mol Ther. 2009 Jul;17(7):1225-33. doi: 10.1038/mt.2009.91. Epub 2009 Apr 28. Mol Ther. 2009. PMID: 19401674 Free PMC article.

3

Naked siLNA-mediated gene silencing of lung bronchoepithelium EGFP expression after intravenous administration.

Glud SZ, Bramsen JB, Dagnaes-Hansen F, Wengel J, Howard KA, Nyengaard JR, Kjems J. Glud SZ, et al. Among authors: howard ka. Oligonucleotides. 2009 Jun;19(2):163-8. doi: 10.1089/oli.2008.0175. Oligonucleotides. 2009. PMID: 19441893

4

Cell type and transfection reagent-dependent effects on viability, cell content, cell cycle and inflammation of RNAi in human primary mesenchymal cells.

Yang HY, Vonk LA, Licht R, van Boxtel AM, Bekkers JE, Kragten AH, Hein S, Varghese OP, Howard KA, Öner FC, Dhert WJ, Creemers LB. Yang HY, et al. Among authors: howard ka. Eur J Pharm Sci. 2014 Mar 12;53:35-44. doi: 10.1016/j.ejps.2013.12.006. Epub 2013 Dec 15. Eur J Pharm Sci. 2014. PMID: 24345796

5

Mucin-mediated nanocarrier disassembly for triggered uptake of oligonucleotides as a delivery strategy for the potential treatment of mucosal tumours.

Martirosyan A, Olesen MJ, Fenton RA, Kjems J, Howard KA. Martirosyan A, et al. Among authors: howard ka. Nanoscale. 2016 Jul 7;8(25):12599-607. doi: 10.1039/c5nr07206a. Epub 2015 Dec 22. Nanoscale. 2016. PMID: 26694897

6

An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing.

Bienk K, Hvam ML, Pakula MM, Dagnæs-Hansen F, Wengel J, Malle BM, Kragh-Hansen U, Cameron J, Bukrinski JT, Howard KA. Bienk K, et al. Among authors: howard ka. J Control Release. 2016 Jun 28;232:143-51. doi: 10.1016/j.jconrel.2016.04.013. Epub 2016 Apr 12. J Control Release. 2016. PMID: 27084489

7

A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis.

Cai Y, López-Ruiz E, Wengel J, Creemers LB, Howard KA. Cai Y, et al. Among authors: howard ka. J Control Release. 2017 May 10;253:153-159. doi: 10.1016/j.jconrel.2017.03.004. Epub 2017 Mar 6. J Control Release. 2017. PMID: 28274742

8

Site-selective conjugation of an anticoagulant aptamer to recombinant albumins and maintenance of neonatal Fc receptor binding.

Schmøkel J, Voldum A, Tsakiridou G, Kuhlmann M, Cameron J, Sørensen ES, Wengel J, Howard KA. Schmøkel J, et al. Among authors: howard ka. Nanotechnology. 2017 May 19;28(20):204004. doi: 10.1088/1361-6528/aa6a9b. Epub 2017 Mar 31. Nanotechnology. 2017. PMID: 28362634

9

Hyaluronic Acid Molecular Weight-Dependent Modulation of Mucin Nanostructure for Potential Mucosal Therapeutic Applications.

Hansen IM, Ebbesen MF, Kaspersen L, Thomsen T, Bienk K, Cai Y, Malle BM, Howard KA. Hansen IM, et al. Among authors: howard ka. Mol Pharm. 2017 Jul 3;14(7):2359-2367. doi: 10.1021/acs.molpharmaceut.7b00236. Epub 2017 May 26. Mol Pharm. 2017. PMID: 28499338

10

Fatty Acid-Modified Gapmer Antisense Oligonucleotide and Serum Albumin Constructs for Pharmacokinetic Modulation.

Hvam ML, Cai Y, Dagnæs-Hansen F, Nielsen JS, Wengel J, Kjems J, Howard KA. Hvam ML, et al. Among authors: howard ka. Mol Ther. 2017 Jul 5;25(7):1710-1717. doi: 10.1016/j.ymthe.2017.05.009. Epub 2017 Jun 20. Mol Ther. 2017. PMID: 28641935 Free PMC article.

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