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Programmable design of orthogonal protein heterodimers.
Chen Z, Boyken SE, Jia M, Busch F, Flores-Solis D, Bick MJ, Lu P, VanAernum ZL, Sahasrabuddhe A, Langan RA, Bermeo S, Brunette TJ, Mulligan VK, Carter LP, DiMaio F, Sgourakis NG, Wysocki VH, Baker D. Chen Z, et al. Nature. 2019 Jan;565(7737):106-111. doi: 10.1038/s41586-018-0802-y. Epub 2018 Dec 19. Nature. 2019. PMID: 30568301 Free PMC article.
De novo design of tunable, pH-driven conformational changes.
Boyken SE, Benhaim MA, Busch F, Jia M, Bick MJ, Choi H, Klima JC, Chen Z, Walkey C, Mileant A, Sahasrabuddhe A, Wei KY, Hodge EA, Byron S, Quijano-Rubio A, Sankaran B, King NP, Lippincott-Schwartz J, Wysocki VH, Lee KK, Baker D. Boyken SE, et al. Among authors: chen z. Science. 2019 May 17;364(6441):658-664. doi: 10.1126/science.aav7897. Science. 2019. PMID: 31097662 Free PMC article.
De novo design of protein logic gates.
Chen Z, Kibler RD, Hunt A, Busch F, Pearl J, Jia M, VanAernum ZL, Wicky BIM, Dods G, Liao H, Wilken MS, Ciarlo C, Green S, El-Samad H, Stamatoyannopoulos J, Wysocki VH, Jewett MC, Boyken SE, Baker D. Chen Z, et al. Science. 2020 Apr 3;368(6486):78-84. doi: 10.1126/science.aay2790. Science. 2020. PMID: 32241946 Free PMC article.
De novo design of bioactive protein switches.
Langan RA, Boyken SE, Ng AH, Samson JA, Dods G, Westbrook AM, Nguyen TH, Lajoie MJ, Chen Z, Berger S, Mulligan VK, Dueber JE, Novak WRP, El-Samad H, Baker D. Langan RA, et al. Among authors: chen z. Nature. 2019 Aug;572(7768):205-210. doi: 10.1038/s41586-019-1432-8. Epub 2019 Jul 24. Nature. 2019. PMID: 31341284 Free PMC article.
Accurate computational design of multipass transmembrane proteins.
Lu P, Min D, DiMaio F, Wei KY, Vahey MD, Boyken SE, Chen Z, Fallas JA, Ueda G, Sheffler W, Mulligan VK, Xu W, Bowie JU, Baker D. Lu P, et al. Among authors: chen z. Science. 2018 Mar 2;359(6379):1042-1046. doi: 10.1126/science.aaq1739. Science. 2018. PMID: 29496880 Free PMC article.
Self-Assembling 2D Arrays with de Novo Protein Building Blocks.
Chen Z, Johnson MC, Chen J, Bick MJ, Boyken SE, Lin B, De Yoreo JJ, Kollman JM, Baker D, DiMaio F. Chen Z, et al. Among authors: chen j. J Am Chem Soc. 2019 Jun 5;141(22):8891-8895. doi: 10.1021/jacs.9b01978. Epub 2019 May 10. J Am Chem Soc. 2019. PMID: 31050411 Free PMC article.
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