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Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA.
Kumar P, Capodagli GC, Awasthi D, Shrestha R, Maharaja K, Sukheja P, Li SG, Inoyama D, Zimmerman M, Ho Liang HP, Sarathy J, Mina M, Rasic G, Russo R, Perryman AL, Richmann T, Gupta A, Singleton E, Verma S, Husain S, Soteropoulos P, Wang Z, Morris R, Porter G, Agnihotri G, Salgame P, Ekins S, Rhee KY, Connell N, Dartois V, Neiditch MB, Freundlich JS, Alland D. Kumar P, et al. Among authors: zimmerman m. mBio. 2018 Dec 18;9(6):e02101-17. doi: 10.1128/mBio.02101-17. mBio. 2018. PMID: 30563908 Free PMC article.
Combining Metabolite-Based Pharmacophores with Bayesian Machine Learning Models for Mycobacterium tuberculosis Drug Discovery.
Ekins S, Madrid PB, Sarker M, Li SG, Mittal N, Kumar P, Wang X, Stratton TP, Zimmerman M, Talcott C, Bourbon P, Travers M, Yadav M, Freundlich JS. Ekins S, et al. Among authors: zimmerman m. PLoS One. 2015 Oct 30;10(10):e0141076. doi: 10.1371/journal.pone.0141076. eCollection 2015. PLoS One. 2015. PMID: 26517557 Free PMC article.
Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis.
Gold B, Smith R, Nguyen Q, Roberts J, Ling Y, Lopez Quezada L, Somersan S, Warrier T, Little D, Pingle M, Zhang D, Ballinger E, Zimmerman M, Dartois V, Hanson P, Mitscher LA, Porubsky P, Rogers S, Schoenen FJ, Nathan C, Aubé J. Gold B, et al. Among authors: zimmerman m. J Med Chem. 2016 Jul 14;59(13):6027-44. doi: 10.1021/acs.jmedchem.5b01833. Epub 2016 Jun 17. J Med Chem. 2016. PMID: 27144688 Free PMC article.
Ethambutol Partitioning in Tuberculous Pulmonary Lesions Explains Its Clinical Efficacy.
Zimmerman M, Lestner J, Prideaux B, O'Brien P, Dias-Freedman I, Chen C, Dietzold J, Daudelin I, Kaya F, Blanc L, Chen PY, Park S, Salgame P, Sarathy J, Dartois V. Zimmerman M, et al. Antimicrob Agents Chemother. 2017 Aug 24;61(9):e00924-17. doi: 10.1128/AAC.00924-17. Print 2017 Sep. Antimicrob Agents Chemother. 2017. PMID: 28696241 Free PMC article.
Coadministration of Allopurinol To Increase Antimycobacterial Efficacy of Pyrazinamide as Evaluated in a Whole-Blood Bactericidal Activity Model.
Naftalin CM, Verma R, Gurumurthy M, Lu Q, Zimmerman M, Yeo BCM, Tan KH, Lin W, Yu B, Dartois V, Paton NI. Naftalin CM, et al. Among authors: zimmerman m. Antimicrob Agents Chemother. 2017 Sep 22;61(10):e00482-17. doi: 10.1128/AAC.00482-17. Print 2017 Oct. Antimicrob Agents Chemother. 2017. PMID: 28739782 Free PMC article. Clinical Trial.
Targeting protein biotinylation enhances tuberculosis chemotherapy.
Tiwari D, Park SW, Essawy MM, Dawadi S, Mason A, Nandakumar M, Zimmerman M, Mina M, Ho HP, Engelhart CA, Ioerger T, Sacchettini JC, Rhee K, Ehrt S, Aldrich CC, Dartois V, Schnappinger D. Tiwari D, et al. Among authors: zimmerman m. Sci Transl Med. 2018 Apr 25;10(438):eaal1803. doi: 10.1126/scitranslmed.aal1803. Sci Transl Med. 2018. PMID: 29695454 Free PMC article.
2,280 results