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ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.
Diercks BP, Werner R, Weidemüller P, Czarniak F, Hernandez L, Lehmann C, Rosche A, Krüger A, Kaufmann U, Vaeth M, Failla AV, Zobiak B, Kandil FI, Schetelig D, Ruthenbeck A, Meier C, Lodygin D, Flügel A, Ren D, Wolf IMA, Feske S, Guse AH. Diercks BP, et al. Among authors: lodygin d. Sci Signal. 2018 Dec 18;11(561):eaat0358. doi: 10.1126/scisignal.aat0358. Sci Signal. 2018. PMID: 30563862 Free PMC article.
HN1L/JPT2: A signaling protein that connects NAADP generation to Ca2+ microdomain formation.
Roggenkamp HG, Khansahib I, Hernandez C LC, Zhang Y, Lodygin D, Krüger A, Gu F, Möckl F, Löhndorf A, Wolters V, Woike D, Rosche A, Bauche A, Schetelig D, Werner R, Schlüter H, Failla AV, Meier C, Fliegert R, Walseth TF, Flügel A, Diercks BP, Guse AH. Roggenkamp HG, et al. Among authors: lodygin d. Sci Signal. 2021 Mar 23;14(675):eabd5647. doi: 10.1126/scisignal.abd5647. Sci Signal. 2021. PMID: 33758062
Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca2+ signaling during T cell activation.
Gu F, Krüger A, Roggenkamp HG, Alpers R, Lodygin D, Jaquet V, Möckl F, Hernandez C LC, Winterberg K, Bauche A, Rosche A, Grasberger H, Kao JY, Schetelig D, Werner R, Schröder K, Carty M, Bowie AG, Huber S, Meier C, Mittrücker HW, Heeren J, Krause KH, Flügel A, Diercks BP, Guse AH. Gu F, et al. Among authors: lodygin d. Sci Signal. 2021 Nov 16;14(709):eabe3800. doi: 10.1126/scisignal.abe3800. Epub 2021 Nov 16. Sci Signal. 2021. PMID: 34784249
T cells become licensed in the lung to enter the central nervous system.
Odoardi F, Sie C, Streyl K, Ulaganathan VK, Schläger C, Lodygin D, Heckelsmiller K, Nietfeld W, Ellwart J, Klinkert WE, Lottaz C, Nosov M, Brinkmann V, Spang R, Lehrach H, Vingron M, Wekerle H, Flügel-Koch C, Flügel A. Odoardi F, et al. Among authors: lodygin d. Nature. 2012 Aug 30;488(7413):675-9. doi: 10.1038/nature11337. Nature. 2012. PMID: 22914092
Effector T-cell trafficking between the leptomeninges and the cerebrospinal fluid.
Schläger C, Körner H, Krueger M, Vidoli S, Haberl M, Mielke D, Brylla E, Issekutz T, Cabañas C, Nelson PJ, Ziemssen T, Rohde V, Bechmann I, Lodygin D, Odoardi F, Flügel A. Schläger C, et al. Among authors: lodygin d. Nature. 2016 Feb 18;530(7590):349-53. doi: 10.1038/nature16939. Epub 2016 Feb 10. Nature. 2016. PMID: 26863192
Laquinimod enhances central nervous system barrier functions.
Lühder F, Kebir H, Odoardi F, Litke T, Sonneck M, Alvarez JI, Winchenbach J, Eckert N, Hayardeny L, Sorani E, Lodygin D, Flügel A, Prat A. Lühder F, et al. Among authors: lodygin d. Neurobiol Dis. 2017 Jun;102:60-69. doi: 10.1016/j.nbd.2017.02.002. Epub 2017 Feb 22. Neurobiol Dis. 2017. PMID: 28235673
β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration.
Lodygin D, Hermann M, Schweingruber N, Flügel-Koch C, Watanabe T, Schlosser C, Merlini A, Körner H, Chang HF, Fischer HJ, Reichardt HM, Zagrebelsky M, Mollenhauer B, Kügler S, Fitzner D, Frahm J, Stadelmann C, Haberl M, Odoardi F, Flügel A. Lodygin D, et al. Nature. 2019 Feb;566(7745):503-508. doi: 10.1038/s41586-019-0964-2. Epub 2019 Feb 20. Nature. 2019. PMID: 30787438
31 results