Himmel H - Search Results

1

Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-yl)pyrido[3,2- d]pyrimidine Based in Vitro Probe BAY-885 for the Kinase ERK5.

Nguyen D, Lemos C, Wortmann L, Eis K, Holton SJ, Boemer U, Moosmayer D, Eberspaecher U, Weiske J, Lechner C, Prechtl S, Suelzle D, Siegel F, Prinz F, Lesche R, Nicke B, Nowak-Reppel K, Himmel H, Mumberg D, von Nussbaum F, Nising CF, Bauser M, Haegebarth A. Nguyen D, et al. Among authors: himmel h. J Med Chem. 2019 Jan 24;62(2):928-940. doi: 10.1021/acs.jmedchem.8b01606. Epub 2019 Jan 9. J Med Chem. 2019. PMID: 30563338

2

Suitability of commonly used excipients for electrophysiological in-vitro safety pharmacology assessment of effects on hERG potassium current and on rabbit Purkinje fiber action potential.

Himmel HM. Himmel HM. J Pharmacol Toxicol Methods. 2007 Sep-Oct;56(2):145-58. doi: 10.1016/j.vascn.2007.04.004. Epub 2007 May 24. J Pharmacol Toxicol Methods. 2007. PMID: 17590357

3

The "induced hyperactivity" test for the de-risking of potential off-target activity of antihypertensive drugs.

Himmel HM, Hoffmann M. Himmel HM, et al. J Pharmacol Toxicol Methods. 2016 Sep-Oct;81:313-22. doi: 10.1016/j.vascn.2016.05.004. Epub 2016 May 11. J Pharmacol Toxicol Methods. 2016. PMID: 27179911

4

Drug-induced functional cardiotoxicity screening in stem cell-derived human and mouse cardiomyocytes: effects of reference compounds.

Himmel HM. Himmel HM. J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):97-111. doi: 10.1016/j.vascn.2013.05.005. Epub 2013 May 20. J Pharmacol Toxicol Methods. 2013. PMID: 23702537

5

QTc shortening with a new investigational cancer drug: a brief case study.

Himmel HM, Hoffmann M. Himmel HM, et al. J Pharmacol Toxicol Methods. 2010 Jul-Aug;62(1):72-81. doi: 10.1016/j.vascn.2010.05.012. Epub 2010 Jun 4. J Pharmacol Toxicol Methods. 2010. PMID: 20570746

6

The arginine-rich hexapeptide R4W2 is a stereoselective antagonist at the vanilloid receptor 1: a Ca2+ imaging study in adult rat dorsal root ganglion neurons.

Himmel HM, Kiss T, Borvendeg SJ, Gillen C, Illes P. Himmel HM, et al. J Pharmacol Exp Ther. 2002 Jun;301(3):981-6. doi: 10.1124/jpet.301.3.981. J Pharmacol Exp Ther. 2002. PMID: 12023528

7

Field and action potential recordings in heart slices: correlation with established in vitro and in vivo models.

Himmel HM, Bussek A, Hoffmann M, Beckmann R, Lohmann H, Schmidt M, Wettwer E. Himmel HM, et al. Br J Pharmacol. 2012 May;166(1):276-96. doi: 10.1111/j.1476-5381.2011.01775.x. Br J Pharmacol. 2012. PMID: 22074238 Free PMC article.

8

Variability of non-clinical behavioral CNS safety assessment: An intercompany comparison.

Himmel HM; Irwin/FOB Consortium Members; Delaunois A, Deurinck M, Dinklo T, Eriksson Faelker TM, Habermann C, Heers C, Hempel K, Lorenz H, Rosch A, Schauerte H, Teuns G, Traebert M, van Amsterdam C, van der Linde H. Himmel HM, et al. J Pharmacol Toxicol Methods. 2019 Sep-Oct;99:106571. doi: 10.1016/j.vascn.2019.03.002. Epub 2019 Mar 27. J Pharmacol Toxicol Methods. 2019. PMID: 30928509

9

Safety pharmacology assessment of drug-induced QT-prolongation in dogs with reduced repolarization reserve.

Vormberge T, Hoffmann M, Himmel H. Vormberge T, et al. Among authors: himmel h. J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):130-40. doi: 10.1016/j.vascn.2006.03.011. Epub 2006 Apr 25. J Pharmacol Toxicol Methods. 2006. PMID: 16757186

10

Safety pharmacology assessment of central nervous system function in juvenile and adult rats: effects of pharmacological reference compounds.

Himmel HM. Himmel HM. J Pharmacol Toxicol Methods. 2008 Sep-Oct;58(2):129-46. doi: 10.1016/j.vascn.2008.06.001. Epub 2008 Jun 8. J Pharmacol Toxicol Methods. 2008. PMID: 18585470

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