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Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor.
Newton AC, Brognard J. Newton AC, et al. Among authors: brognard j. Trends Pharmacol Sci. 2017 May;38(5):438-447. doi: 10.1016/j.tips.2017.02.002. Epub 2017 Mar 8. Trends Pharmacol Sci. 2017. PMID: 28283201 Free PMC article. Review.
Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases.
Hudson AM, Stephenson NL, Li C, Trotter E, Fletcher AJ, Katona G, Bieniasz-Krzywiec P, Howell M, Wirth C, Furney S, Miller CJ, Brognard J. Hudson AM, et al. Among authors: brognard j. Sci Signal. 2018 Apr 17;11(526):eaan6776. doi: 10.1126/scisignal.aan6776. Sci Signal. 2018. PMID: 29666306 Free PMC article.
Signaling pathway screening platforms are an efficient approach to identify therapeutic targets in cancers that lack known driver mutations: a case report for a cancer of unknown primary origin.
Torres-Ayuso P, Sahoo S, Ashton G, An E, Simms N, Galvin M, Leong HS, Frese KK, Simpson K, Cook N, Hughes A, Miller CJ, Marais R, Dive C, Krebs MG, Brognard J. Torres-Ayuso P, et al. Among authors: brognard j. NPJ Genom Med. 2018 Jun 20;3:15. doi: 10.1038/s41525-018-0055-6. eCollection 2018. NPJ Genom Med. 2018. PMID: 29951225 Free PMC article.
TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin.
Torres-Ayuso P, An E, Nyswaner KM, Bensen RC, Ritt DA, Specht SI, Das S, Andresson T, Cachau RE, Liang RJ, Ries AL, Robinson CM, Difilippantonio S, Gouker B, Bassel L, Karim BO, Miller CJ, Turk BE, Morrison DK, Brognard J. Torres-Ayuso P, et al. Among authors: brognard j. Cancer Discov. 2021 Jun;11(6):1411-1423. doi: 10.1158/2159-8290.CD-20-0797. Epub 2021 Jan 25. Cancer Discov. 2021. PMID: 33495197 Free PMC article.
45 results