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Haloperidol and Risperidone at high concentrations activate an in vitro inflammatory response of RAW 264.7 macrophage cells by induction of apoptosis and modification of cytokine levels.
da Cruz Jung IE, Machado AK, da Cruz IB, Barbisan F, Azzolin VF, Duarte T, Duarte MM, do Prado-Lima PA, Bochi GV, Scola G, Moresco RN. da Cruz Jung IE, et al. Psychopharmacology (Berl). 2016 May;233(9):1715-23. doi: 10.1007/s00213-015-4079-7. Epub 2015 Sep 21. Psychopharmacology (Berl). 2016. PMID: 26391290
Lithium is able to minimize olanzapine oxidative-inflammatory induction on macrophage cells.
Fernandes MS, Barbisan F, Azzolin VF, do Prado-Lima PAS, Teixeira CF, da Cruz Jung IE, Assmann CE, Riffel RT, Duarte MMMF, Aguiar-Ribeiro EM, da Cruz IBM. Fernandes MS, et al. Among authors: da cruz jung ie. PLoS One. 2019 Jan 29;14(1):e0209223. doi: 10.1371/journal.pone.0209223. eCollection 2019. PLoS One. 2019. PMID: 30695037 Free PMC article.
Unmetabolized quetiapine exerts an in vitro effect on innate immune cells by modulating inflammatory response and neutrophil extracellular trap formation.
Turra BO, Barbisan F, Azzolin VF, Teixeira CF, Flores T, Braun LE, de Oliveira Nerys DA, Rissi VB, de Oliveira Alves A, Assmann CE, da Cruz Jung IE, Marques LPS, da Cruz IBM. Turra BO, et al. Among authors: da cruz jung ie. Biomed Pharmacother. 2020 Nov;131:110497. doi: 10.1016/j.biopha.2020.110497. Epub 2020 Oct 7. Biomed Pharmacother. 2020. PMID: 33152899 Free article.
Superoxide imbalance triggered by Val16Ala-SOD2 polymorphism increases the risk of depression and self-reported psychological stress in free-living elderly people.
da Cruz Jung IE, da Cruz IBM, Barbisan F, Trott A, Houenou LJ, Osmarin Turra B, Duarte T, de Souza Praia R, Maia-Ribeiro EA, da Costa Escobar Piccoli J, Bica CG, Duarte MMMF. da Cruz Jung IE, et al. Mol Genet Genomic Med. 2020 Feb;8(2):e1080. doi: 10.1002/mgg3.1080. Epub 2019 Dec 31. Mol Genet Genomic Med. 2020. PMID: 31891227 Free PMC article.