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Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.
Campa CC, Silva RL, Margaria JP, Pirali T, Mattos MS, Kraemer LR, Reis DC, Grosa G, Copperi F, Dalmarco EM, Lima-Júnior RCP, Aprile S, Sala V, Dal Bello F, Prado DS, Alves-Filho JC, Medana C, Cassali GD, Tron GC, Teixeira MM, Ciraolo E, Russo RC, Hirsch E. Campa CC, et al. Among authors: silva rl. Nat Commun. 2018 Dec 12;9(1):5232. doi: 10.1038/s41467-018-07698-6. Nat Commun. 2018. PMID: 30542075 Free PMC article.
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.
Pirali T, Ciraolo E, Aprile S, Massarotti A, Berndt A, Griglio A, Serafini M, Mercalli V, Landoni C, Campa CC, Margaria JP, Silva RL, Grosa G, Sorba G, Williams R, Hirsch E, Tron GC. Pirali T, et al. Among authors: silva rl. ChemMedChem. 2017 Sep 21;12(18):1542-1554. doi: 10.1002/cmdc.201700340. Epub 2017 Aug 31. ChemMedChem. 2017. PMID: 28857471 Free PMC article.
Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis.
Czaikoski PG, Mota JM, Nascimento DC, Sônego F, Castanheira FV, Melo PH, Scortegagna GT, Silva RL, Barroso-Sousa R, Souto FO, Pazin-Filho A, Figueiredo F, Alves-Filho JC, Cunha FQ. Czaikoski PG, et al. Among authors: silva rl. PLoS One. 2016 Feb 5;11(2):e0148142. doi: 10.1371/journal.pone.0148142. eCollection 2016. PLoS One. 2016. PMID: 26849138 Free PMC article.
Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner.
Wanderley CW, Colón DF, Luiz JPM, Oliveira FF, Viacava PR, Leite CA, Pereira JA, Silva CM, Silva CR, Silva RL, Speck-Hernandez CA, Mota JM, Alves-Filho JC, Lima-Junior RC, Cunha TM, Cunha FQ. Wanderley CW, et al. Among authors: silva cr, silva cm, silva rl. Cancer Res. 2018 Oct 15;78(20):5891-5900. doi: 10.1158/0008-5472.CAN-17-3480. Epub 2018 Aug 13. Cancer Res. 2018. PMID: 30104241
The Adaptor Protein Myd88 Is a Key Signaling Molecule in the Pathogenesis of Irinotecan-Induced Intestinal Mucositis.
Wong DV, Lima-Júnior RC, Carvalho CB, Borges VF, Wanderley CW, Bem AX, Leite CA, Teixeira MA, Batista GL, Silva RL, Cunha TM, Brito GA, Almeida PR, Cunha FQ, Ribeiro RA. Wong DV, et al. Among authors: silva rl. PLoS One. 2015 Oct 6;10(10):e0139985. doi: 10.1371/journal.pone.0139985. eCollection 2015. PLoS One. 2015. PMID: 26440613 Free PMC article.
Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state.
Trevelin SC, Dos Santos CX, Ferreira RG, de Sá Lima L, Silva RL, Scavone C, Curi R, Alves-Filho JC, Cunha TM, Roxo-Júnior P, Cervi MC, Laurindo FR, Hothersall JS, Cobb AM, Zhang M, Ivetic A, Shah AM, Lopes LR, Cunha FQ. Trevelin SC, et al. Among authors: silva rl. Sci Rep. 2016 Oct 4;6:34581. doi: 10.1038/srep34581. Sci Rep. 2016. PMID: 27698473 Free PMC article.
Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-κB.
Ruiz-Miyazawa KW, Pinho-Ribeiro FA, Zarpelon AC, Staurengo-Ferrari L, Silva RL, Alves-Filho JC, Cunha TM, Cunha FQ, Casagrande R, Verri WA Jr. Ruiz-Miyazawa KW, et al. Among authors: silva rl. Chem Biol Interact. 2015 Jul 25;237:9-17. doi: 10.1016/j.cbi.2015.05.007. Epub 2015 May 14. Chem Biol Interact. 2015. PMID: 25980587 Free article.
Cinnamoyloxy-mammeisin Isolated from Geopropolis Attenuates Inflammatory Process by Inhibiting Cytokine Production: Involvement of MAPK, AP-1, and NF-κB.
Franchin M, Rosalen PL, da Cunha MG, Silva RL, Colón DF, Bassi GS, de Alencar SM, Ikegaki M, Alves-Filho JC, Cunha FQ, Beutler JA, Cunha TM. Franchin M, et al. Among authors: silva rl. J Nat Prod. 2016 Jul 22;79(7):1828-33. doi: 10.1021/acs.jnatprod.6b00263. Epub 2016 Jul 1. J Nat Prod. 2016. PMID: 27367493 Free PMC article.
Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia.
Silva JR, Lopes AH, Talbot J, Cecilio NT, Rossato MF, Silva RL, Souza GR, Silva CR, Lucas G, Fonseca BA, Arruda E, Alves-Filho JC, Cunha FQ, Cunha TM. Silva JR, et al. Among authors: silva cr, silva rl. J Neurosci. 2017 Jul 5;37(27):6408-6422. doi: 10.1523/JNEUROSCI.2233-16.2017. Epub 2017 Jun 2. J Neurosci. 2017. PMID: 28576938 Free PMC article.
286 results