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Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.
Campa CC, Silva RL, Margaria JP, Pirali T, Mattos MS, Kraemer LR, Reis DC, Grosa G, Copperi F, Dalmarco EM, Lima-Júnior RCP, Aprile S, Sala V, Dal Bello F, Prado DS, Alves-Filho JC, Medana C, Cassali GD, Tron GC, Teixeira MM, Ciraolo E, Russo RC, Hirsch E. Campa CC, et al. Nat Commun. 2018 Dec 12;9(1):5232. doi: 10.1038/s41467-018-07698-6. Nat Commun. 2018. PMID: 30542075 Free PMC article.
Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.
Pirali T, Ciraolo E, Aprile S, Massarotti A, Berndt A, Griglio A, Serafini M, Mercalli V, Landoni C, Campa CC, Margaria JP, Silva RL, Grosa G, Sorba G, Williams R, Hirsch E, Tron GC. Pirali T, et al. Among authors: campa cc. ChemMedChem. 2017 Sep 21;12(18):1542-1554. doi: 10.1002/cmdc.201700340. Epub 2017 Aug 31. ChemMedChem. 2017. PMID: 28857471 Free PMC article.
Genetic Deletion and Pharmacological Inhibition of PI3K γ Reduces Neutrophilic Airway Inflammation and Lung Damage in Mice with Cystic Fibrosis-Like Lung Disease.
Galluzzo M, Ciraolo E, Lucattelli M, Hoxha E, Ulrich M, Campa CC, Lungarella G, Doring G, Zhou-Suckow Z, Mall M, Hirsch E, De Rose V. Galluzzo M, et al. Among authors: campa cc. Mediators Inflamm. 2015;2015:545417. doi: 10.1155/2015/545417. Epub 2015 Jun 21. Mediators Inflamm. 2015. PMID: 26185363 Free PMC article.
New pre-clinical evidence of anti-inflammatory effect and safety of a substituted fluorophenyl imidazole.
Dos Santos Nascimento MVP, Mattar Munhoz AC, De Campos Facchin BM, Fratoni E, Rossa TA, Mandolesi Sá M, Campa CC, Ciraolo E, Hirsch E, Dalmarco EM. Dos Santos Nascimento MVP, et al. Among authors: campa cc. Biomed Pharmacother. 2019 Mar;111:1399-1407. doi: 10.1016/j.biopha.2019.01.052. Epub 2019 Jan 19. Biomed Pharmacother. 2019. PMID: 30841455 Free article.
Crossroads of PI3K and Rac pathways.
Campa CC, Ciraolo E, Ghigo A, Germena G, Hirsch E. Campa CC, et al. Small GTPases. 2015;6(2):71-80. doi: 10.4161/21541248.2014.989789. Epub 2015 May 5. Small GTPases. 2015. PMID: 25942647 Free PMC article. Review.
Targeting PI3K signaling in cancer: Challenges and advances.
De Santis MC, Gulluni F, Campa CC, Martini M, Hirsch E. De Santis MC, et al. Among authors: campa cc. Biochim Biophys Acta Rev Cancer. 2019 Apr;1871(2):361-366. doi: 10.1016/j.bbcan.2019.03.003. Epub 2019 Apr 1. Biochim Biophys Acta Rev Cancer. 2019. PMID: 30946868 Review.
25 results