Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

Search Results

163 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Results By Year timeline is not available.
Page 1
Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.
Uno T, Kawai Y, Yamashita S, Oshiumi H, Yoshimura C, Mizutani T, Suzuki T, Chong KT, Shigeno K, Ohkubo M, Kodama Y, Muraoka H, Funabashi K, Takahashi K, Ohkubo S, Kitade M. Uno T, et al. Among authors: yoshimura c. J Med Chem. 2019 Jan 24;62(2):531-551. doi: 10.1021/acs.jmedchem.8b01085. Epub 2018 Dec 21. J Med Chem. 2019. PMID: 30525599
Thermodynamic Dissection of Potency and Selectivity of Cytosolic Hsp90 Inhibitors.
Yoshimura C, Nagatoishi S, Kuroda D, Kodama Y, Uno T, Kitade M, Chong-Takata K, Oshiumi H, Muraoka H, Yamashita S, Kawai Y, Ohkubo S, Tsumoto K. Yoshimura C, et al. J Med Chem. 2021 Mar 11;64(5):2669-2677. doi: 10.1021/acs.jmedchem.0c01715. Epub 2021 Feb 23. J Med Chem. 2021. PMID: 33621080 Free article.
TAS-116, a highly selective inhibitor of heat shock protein 90α and β, demonstrates potent antitumor activity and minimal ocular toxicity in preclinical models.
Ohkubo S, Kodama Y, Muraoka H, Hitotsumachi H, Yoshimura C, Kitade M, Hashimoto A, Ito K, Gomori A, Takahashi K, Shibata Y, Kanoh A, Yonekura K. Ohkubo S, et al. Among authors: yoshimura c. Mol Cancer Ther. 2015 Jan;14(1):14-22. doi: 10.1158/1535-7163.MCT-14-0219. Epub 2014 Nov 21. Mol Cancer Ther. 2015. PMID: 25416789
TAS4464, A Highly Potent and Selective Inhibitor of NEDD8-Activating Enzyme, Suppresses Neddylation and Shows Antitumor Activity in Diverse Cancer Models.
Yoshimura C, Muraoka H, Ochiiwa H, Tsuji S, Hashimoto A, Kazuno H, Nakagawa F, Komiya Y, Suzuki S, Takenaka T, Kumazaki M, Fujita N, Mizutani T, Ohkubo S. Yoshimura C, et al. Mol Cancer Ther. 2019 Jul;18(7):1205-1216. doi: 10.1158/1535-7163.MCT-18-0644. Epub 2019 May 15. Mol Cancer Ther. 2019. PMID: 31092565
TAS4464, a NEDD8-activating enzyme inhibitor, activates both intrinsic and extrinsic apoptotic pathways via c-Myc-mediated regulation in acute myeloid leukemia.
Ochiiwa H, Ailiken G, Yokoyama M, Yamagata K, Nagano H, Yoshimura C, Muraoka H, Ishida K, Haruma T, Nakayama A, Hashimoto N, Murata K, Nishimura M, Kawashima Y, Ohara O, Ohkubo S, Tanaka T. Ochiiwa H, et al. Among authors: yoshimura c. Oncogene. 2021 Feb;40(7):1217-1230. doi: 10.1038/s41388-020-01586-4. Epub 2021 Jan 8. Oncogene. 2021. PMID: 33420360 Free PMC article.
Nucleic acid-triggered tumoral immunity propagates pH-selective therapeutic antibodies through tumor-driven epitope spreading.
Furuya G, Katoh H, Atsumi S, Hashimoto I, Komura D, Hatanaka R, Senga S, Hayashi S, Akita S, Matsumura H, Miura A, Mita H, Nakakido M, Nagatoishi S, Sugiyama A, Suzuki R, Konishi H, Yamamoto A, Abe H, Hiraoka N, Aoki K, Kato Y, Seto Y, Yoshimura C, Miyadera K, Tsumoto K, Ushiku T, Ishikawa S. Furuya G, et al. Among authors: yoshimura c. Cancer Sci. 2023 Jan;114(1):321-338. doi: 10.1111/cas.15596. Epub 2022 Oct 17. Cancer Sci. 2023. PMID: 36136061 Free PMC article.
Human activities shape global patterns of decomposition rates in rivers.
Tiegs SD, Capps KA, Costello DM, Schmidt JP, Patrick CJ, Follstad Shah JJ, LeRoy CJ; CELLDEX Consortium‡; Acuña V, Albariño R, Allen DC, Alonso C, Andino P, Arango C, Aroviita J, Barbosa MVM, Barmuta LA, Baxter C, Bellinger B, Boyero L, Bragina L, Brown LE, Bruder A, Bruesewitz DA, Burdon F, Callisto M, Camacho A, Canhoto C, Castillo MM, Chauvet E, Clapcott J, Colas F, Colón-Gaud C, Cornut J, Crespo-Pérez V, Cross WF, Culp J, Danger M, Dangles O, de Eyto E, Derry AM, Villanueva VD, Douglas MM, Elosegi A, Encalada AC, Entrekin S, Espinosa R, Ferreira V, Ferriol C, Flanagan KM, Flecker AS, Fleituch T, Frainer A, Friberg N, Frost PC, Garcia EA, García-Lago L, Soto PEG, Gessner MO, Ghate S, Giling DP, Gilmer A, Gonçalves JF Jr, Gonzales RK, Graça MAS, Grace M, Griffiths NA, Grossart HP, Guérold F, Gulis V, Gutiérrez-Fonseca PE, Hepp LU, Higgins S, Hishi T, Huddart J, Hudson J, Imberger M, Iñiguez-Armijos C, Isken MW, Iwata T, Janetski DJ, Kirkwood AE, Koning AA, Kosten S, Kuehn KA, Laudon H, Leavitt PR, Lemes da Silva AL, Leroux S, Lisi PJ, MacKenzie R, Marcarelli AM, Masese FO, McIntyre PB, McKie BG, Medeiros A, Meissner K, Miliša M, Mishra S, Miyake Y, Moerke A, Mombrikotb S, Mooney… See abstract for full author list ➔ Tiegs SD, et al. Among authors: yoshimura c. Science. 2024 May 30:eadn1262. doi: 10.1126/science.adn1262. Online ahead of print. Science. 2024. PMID: 38815088
163 results