Uno T - Search Results

1

Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.

Uno T, Kawai Y, Yamashita S, Oshiumi H, Yoshimura C, Mizutani T, Suzuki T, Chong KT, Shigeno K, Ohkubo M, Kodama Y, Muraoka H, Funabashi K, Takahashi K, Ohkubo S, Kitade M. Uno T, et al. J Med Chem. 2019 Jan 24;62(2):531-551. doi: 10.1021/acs.jmedchem.8b01085. Epub 2018 Dec 21. J Med Chem. 2019. PMID: 30525599

2

Thermodynamic Dissection of Potency and Selectivity of Cytosolic Hsp90 Inhibitors.

Yoshimura C, Nagatoishi S, Kuroda D, Kodama Y, Uno T, Kitade M, Chong-Takata K, Oshiumi H, Muraoka H, Yamashita S, Kawai Y, Ohkubo S, Tsumoto K. Yoshimura C, et al. Among authors: uno t. J Med Chem. 2021 Mar 11;64(5):2669-2677. doi: 10.1021/acs.jmedchem.0c01715. Epub 2021 Feb 23. J Med Chem. 2021. PMID: 33621080 Free article.

3

Structure-activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity.

Nagumo Y, Kakeya H, Yamaguchi J, Uno T, Shoji M, Hayashi Y, Osada H. Nagumo Y, et al. Among authors: uno t. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4425-9. doi: 10.1016/j.bmcl.2004.06.054. Bioorg Med Chem Lett. 2004. PMID: 15357965

4

TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations.

Hasako S, Terasaka M, Abe N, Uno T, Ohsawa H, Hashimoto A, Fujita R, Tanaka K, Okayama T, Wadhwa R, Miyadera K, Aoyagi Y, Yonekura K, Matsuo K. Hasako S, et al. Among authors: uno t. Mol Cancer Ther. 2018 Aug;17(8):1648-1658. doi: 10.1158/1535-7163.MCT-17-1206. Epub 2018 May 10. Mol Cancer Ther. 2018. PMID: 29748209

5

Stereoselective total synthesis of ent-EI-1941-2 and Epi-ent-EI-1941-2.

Shoji M, Uno T, Hayashi Y. Shoji M, et al. Among authors: uno t. Org Lett. 2004 Nov 25;6(24):4535-8. doi: 10.1021/ol0481479. Org Lett. 2004. PMID: 15548069

6

Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells.

Yamaguchi J, Kakeya H, Uno T, Shoji M, Osada H, Hayashi Y. Yamaguchi J, et al. Among authors: uno t. Angew Chem Int Ed Engl. 2005 May 13;44(20):3110-5. doi: 10.1002/anie.200500060. Angew Chem Int Ed Engl. 2005. PMID: 15832392 No abstract available.

7

Enantio- and diastereoselective total synthesis of EI-1941-1, -2, and -3, inhibitors of interleukin-1beta converting enzyme, and biological properties of their derivatives.

Shoji M, Uno T, Kakeya H, Onose R, Shiina I, Osada H, Hayashi Y. Shoji M, et al. Among authors: uno t. J Org Chem. 2005 Nov 25;70(24):9905-15. doi: 10.1021/jo0516436. J Org Chem. 2005. PMID: 16292821

8

Antiarrhythmic properties of 5-(3-tert-butylamino-2-hydroxy)propoxy-3,4-dihydrocarbostyril hydrochloride (OPC-1085), a newly synthesized, potent beta-adrenoreceptor antagonist.

Yabuuchi Y, Hashimoto K, Yamashita S, Uno T, Shintani S, Nakagiri N. Yabuuchi Y, et al. Among authors: uno t. Clin Exp Pharmacol Physiol. 1977 Nov-Dec;4(6):545-59. doi: 10.1111/j.1440-1681.1977.tb02684.x. Clin Exp Pharmacol Physiol. 1977. PMID: 22416

9

A pilot study on interobserver variability in organ-at-risk contours in magnetic resonance imaging-guided online adaptive radiotherapy for pancreatic cancer.

Kurokawa M, Tsuneda M, Abe K, Ikeda Y, Kanazawa A, Saito M, Kodate A, Harada R, Yokota H, Watanabe M, Uno T. Kurokawa M, et al. Among authors: uno t. Front Oncol. 2024 May 10;14:1335623. doi: 10.3389/fonc.2024.1335623. eCollection 2024. Front Oncol. 2024. PMID: 38800394 Free PMC article.

10

Plasminogen activator inhibitor-1 promotes immune evasion in tumors by facilitating the expression of programmed cell death-ligand 1.

Ibrahim AA, Fujimura T, Uno T, Terada T, Hirano KI, Hosokawa H, Ohta A, Miyata T, Ando K, Yahata T. Ibrahim AA, et al. Among authors: uno t. Front Immunol. 2024 May 8;15:1365894. doi: 10.3389/fimmu.2024.1365894. eCollection 2024. Front Immunol. 2024. PMID: 38779680 Free PMC article.

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