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Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.
Uno T, Kawai Y, Yamashita S, Oshiumi H, Yoshimura C, Mizutani T, Suzuki T, Chong KT, Shigeno K, Ohkubo M, Kodama Y, Muraoka H, Funabashi K, Takahashi K, Ohkubo S, Kitade M. Uno T, et al. Among authors: oshiumi h. J Med Chem. 2019 Jan 24;62(2):531-551. doi: 10.1021/acs.jmedchem.8b01085. Epub 2018 Dec 21. J Med Chem. 2019. PMID: 30525599
Thermodynamic Dissection of Potency and Selectivity of Cytosolic Hsp90 Inhibitors.
Yoshimura C, Nagatoishi S, Kuroda D, Kodama Y, Uno T, Kitade M, Chong-Takata K, Oshiumi H, Muraoka H, Yamashita S, Kawai Y, Ohkubo S, Tsumoto K. Yoshimura C, et al. Among authors: oshiumi h. J Med Chem. 2021 Mar 11;64(5):2669-2677. doi: 10.1021/acs.jmedchem.0c01715. Epub 2021 Feb 23. J Med Chem. 2021. PMID: 33621080 Free article.
Supersulphides provide airway protection in viral and chronic lung diseases.
Matsunaga T, Sano H, Takita K, Morita M, Yamanaka S, Ichikawa T, Numakura T, Ida T, Jung M, Ogata S, Yoon S, Fujino N, Kyogoku Y, Sasaki Y, Koarai A, Tamada T, Toyama A, Nakabayashi T, Kageyama L, Kyuwa S, Inaba K, Watanabe S, Nagy P, Sawa T, Oshiumi H, Ichinose M, Yamada M, Sugiura H, Wei FY, Motohashi H, Akaike T. Matsunaga T, et al. Among authors: oshiumi h. Nat Commun. 2023 Jul 25;14(1):4476. doi: 10.1038/s41467-023-40182-4. Nat Commun. 2023. PMID: 37491435 Free PMC article.
NOP16 is a histone mimetic that regulates Histone H3K27 methylation and gene repression.
Takashima K, Lee DJ, Trovero MF, Rothi MH, Mistry M, Zhang Y, Li Z, Davis CP, Li Z, Natale J, Schmid E, Al Haddad J, Hoffmann GB, Dietmann S, Sui SH, Oshiumi H, Lieberman J, Greer EL. Takashima K, et al. Among authors: oshiumi h. bioRxiv [Preprint]. 2023 Jun 13:2023.06.13.544862. doi: 10.1101/2023.06.13.544862. bioRxiv. 2023. PMID: 37397991 Free PMC article. Preprint.
Evaluation of Neutralizing Activity against Omicron Subvariants in BA.5 Breakthrough Infection and Three-Dose Vaccination Using a Novel Chemiluminescence-Based, Virus-Mediated Cytopathic Assay.
Toyoda M, Tan TS, Motozono C, Barabona G, Yonekawa A, Shimono N, Minami R, Nagasaki Y, Miyashita Y, Oshiumi H, Nakamura K, Matsushita S, Kuwata T, Ueno T. Toyoda M, et al. Among authors: oshiumi h. Microbiol Spectr. 2023 Aug 17;11(4):e0066023. doi: 10.1128/spectrum.00660-23. Epub 2023 Jun 13. Microbiol Spectr. 2023. PMID: 37310218 Free PMC article.
131 results