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Chemically modified peanut extract shows increased safety while maintaining immunogenicity.
Allergy. 2019 May;74(5):986-995. doi: 10.1111/all.13687. Epub 2018 Dec 27.
Allergy. 2019.
PMID: 30506686
Reduction and alkylation of peanut allergen isoforms Ara h 2 and Ara h 6; characterization of intermediate- and end products.
Apostolovic D, Luykx D, Warmenhoven H, Verbart D, Stanic-Vucinic D, de Jong GA, Velickovic TC, Koppelman SJ.
Apostolovic D, et al.
Biochim Biophys Acta. 2013 Dec;1834(12):2832-42. doi: 10.1016/j.bbapap.2013.10.004. Epub 2013 Oct 18.
Biochim Biophys Acta. 2013.
PMID: 24145103
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Bet v 1-displaying elastin-like polypeptide nanoparticles induce a strong humoral and weak CD4+ T-cell response against Bet v 1 in a murine immunogenicity model.
van Strien J, Warmenhoven H, Logiantara A, Makurat M, Aglas L, Bethanis A, Leboux R, van Rijt L, MacKay JA, van Schijndel JW, Schneider G, Olsthoorn R, Jiskoot W, van Ree R, Kros A.
van Strien J, et al.
Front Immunol. 2022 Oct 6;13:1006776. doi: 10.3389/fimmu.2022.1006776. eCollection 2022.
Front Immunol. 2022.
PMID: 36275650
Free PMC article.
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Cationic liposomes bearing Bet v 1 by coiled coil-formation are hypo-allergenic and induce strong immunogenicity in mice.
Warmenhoven H, Leboux R, Bethanis A, van Strien J, Logiantara A, van Schijndel H, Aglas L, van Rijt L, Slütter B, Kros A, Jiskoot W, van Ree R.
Warmenhoven H, et al.
Front Allergy. 2023 Jan 10;3:1092262. doi: 10.3389/falgy.2022.1092262. eCollection 2022.
Front Allergy. 2023.
PMID: 36704756
Free PMC article.
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IgE cross-inhibition between Ara h 1 and Ara h 2 is explained by complex formation of both major peanut allergens.
Warmenhoven HJM, Hulsbos L, Dreskin SC, Akkerdaas JH, Versteeg SA, van Ree R.
Warmenhoven HJM, et al.
J Allergy Clin Immunol. 2023 Aug;152(2):436-444.e6. doi: 10.1016/j.jaci.2023.03.025. Epub 2023 Apr 5.
J Allergy Clin Immunol. 2023.
PMID: 37028524
Free PMC article.
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