The metal cofactor zinc and interacting membranes modulate SOD1 conformation-aggregation landscape in an in vitro ALS model.
Sannigrahi A, Chowdhury S, Das B, Banerjee A, Halder A, Kumar A, Saleem M, Naganathan AN, Karmakar S, Chattopadhyay K.
Sannigrahi A, et al. Among authors: chowdhury s.
Elife. 2021 Apr 7;10:e61453. doi: 10.7554/eLife.61453.
Elife. 2021.
PMID: 33825682
Free PMC article.
Experiments on these mutated proteins showed that the copper ion is responsible for the protein's role in neutralizing harmful reactive molecules, while the zinc ion stabilizes the protein against aggregation. ...This discovery could help design new ALS treatments that tar …
Experiments on these mutated proteins showed that the copper ion is responsible for the protein's role in neutralizing harmful reacti …