Miyachi H - Search Results

1

Development of FABP3 ligands that inhibit arachidonic acid-induced α-synuclein oligomerization.

Cheng A, Shinoda Y, Yamamoto T, Miyachi H, Fukunaga K. Cheng A, et al. Among authors: miyachi h. Brain Res. 2019 Mar 15;1707:190-197. doi: 10.1016/j.brainres.2018.11.036. Epub 2018 Nov 26. Brain Res. 2019. PMID: 30496735

2

Inhibition of MPTP-induced α-synuclein oligomerization by fatty acid-binding protein 3 ligand in MPTP-treated mice.

Matsuo K, Cheng A, Yabuki Y, Takahata I, Miyachi H, Fukunaga K. Matsuo K, et al. Among authors: miyachi h. Neuropharmacology. 2019 May 15;150:164-174. doi: 10.1016/j.neuropharm.2019.03.029. Epub 2019 Mar 28. Neuropharmacology. 2019. PMID: 30930168

3

Novel fatty acid-binding protein 3 ligand inhibits dopaminergic neuronal death and improves motor and cognitive impairments in Parkinson's disease model mice.

Haga H, Yamada R, Izumi H, Shinoda Y, Kawahata I, Miyachi H, Fukunaga K. Haga H, et al. Among authors: miyachi h. Pharmacol Biochem Behav. 2020 Apr;191:172891. doi: 10.1016/j.pbb.2020.172891. Epub 2020 Feb 29. Pharmacol Biochem Behav. 2020. PMID: 32126223

4

Analysis of binding affinity and docking of novel fatty acid-binding protein (FABP) ligands.

Shinoda Y, Wang Y, Yamamoto T, Miyachi H, Fukunaga K. Shinoda Y, et al. Among authors: miyachi h. J Pharmacol Sci. 2020 Aug;143(4):264-271. doi: 10.1016/j.jphs.2020.05.005. Epub 2020 May 23. J Pharmacol Sci. 2020. PMID: 32499096 Free article.

5

Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.

Kuwabara N, Oyama T, Tomioka D, Ohashi M, Yanagisawa J, Shimizu T, Miyachi H. Kuwabara N, et al. Among authors: miyachi h. J Med Chem. 2012 Jan 26;55(2):893-902. doi: 10.1021/jm2014293. Epub 2012 Jan 10. J Med Chem. 2012. PMID: 22185225

6

Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands.

Beniyama Y, Matsuno K, Miyachi H. Beniyama Y, et al. Among authors: miyachi h. Bioorg Med Chem Lett. 2013 Mar 15;23(6):1662-6. doi: 10.1016/j.bmcl.2013.01.054. Epub 2013 Jan 26. Bioorg Med Chem Lett. 2013. PMID: 23395658

7

Crystal Structures of the Human Peroxisome Proliferator-Activated Receptor (PPAR)α Ligand-Binding Domain in Complexes with a Series of Phenylpropanoic Acid Derivatives Generated by a Ligand-Exchange Soaking Method.

Oyama T, Kamata S, Ishii I, Miyachi H. Oyama T, et al. Among authors: miyachi h. Biol Pharm Bull. 2021;44(9):1202-1209. doi: 10.1248/bpb.b21-00220. Biol Pharm Bull. 2021. PMID: 34471048 Free article.

8

Structural Biology Inspired Development of a Series of Human Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Ligands: From Agonist to Antagonist.

Miyachi H. Miyachi H. Int J Mol Sci. 2023 Feb 15;24(4):3940. doi: 10.3390/ijms24043940. Int J Mol Sci. 2023. PMID: 36835351 Free PMC article. Review.

9

Discovery of peroxisome proliferator-activated receptor α (PPARα) activators with a ligand-screening system using a human PPARα-expressing cell line.

Tachibana K, Yuzuriha T, Tabata R, Fukuda S, Maegawa T, Takahashi R, Tanimoto K, Tsujino H, Nunomura K, Lin B, Matsuura Y, Tanaka T, Hamakubo T, Sakai J, Kodama T, Kobayashi T, Ishimoto K, Miyachi H, Doi T. Tachibana K, et al. Among authors: miyachi h. J Biol Chem. 2018 Jun 29;293(26):10333-10343. doi: 10.1074/jbc.RA118.002077. Epub 2018 May 15. J Biol Chem. 2018. PMID: 29764933 Free PMC article.

10

Inhibitory Effects of a Novel PPAR-γ Agonist MEKT1 on Pomc Expression/ACTH Secretion in AtT20 Cells.

Parvin R, Noro E, Saito-Hakoda A, Shimada H, Suzuki S, Shimizu K, Miyachi H, Yokoyama A, Sugawara A. Parvin R, et al. Among authors: miyachi h. PPAR Res. 2018 Apr 23;2018:5346272. doi: 10.1155/2018/5346272. eCollection 2018. PPAR Res. 2018. PMID: 29849538 Free PMC article.

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