Ogiyama T - Search Results

1

Perturbation-Based Proteomic Correlation Profiling as a Target Deconvolution Methodology.

Ohki Y, Sakurai H, Hoshino M, Terashima H, Shimizu H, Ishikawa T, Ogiyama T, Muramatsu Y, Nakanishi T, Miyazaki S, Tsuruoka H, Kobayashi H, Kubota K. Ohki Y, et al. Among authors: ogiyama t. Cell Chem Biol. 2019 Jan 17;26(1):137-143.e8. doi: 10.1016/j.chembiol.2018.10.012. Epub 2018 Nov 15. Cell Chem Biol. 2019. PMID: 30449674 Free article.

2

Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor.

Ogiyama T, Yamaguchi M, Kurikawa N, Honzumi S, Terayama K, Nagaoka N, Yamamoto Y, Kimura T, Sugiyama D, Inoue SI. Ogiyama T, et al. Bioorg Med Chem. 2017 Sep 1;25(17):4817-4828. doi: 10.1016/j.bmc.2017.07.028. Epub 2017 Jul 17. Bioorg Med Chem. 2017. PMID: 28756012

3

Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation.

Ogiyama T, Yamaguchi M, Kurikawa N, Honzumi S, Yamamoto Y, Sugiyama D, Takakusa H, Inoue SI. Ogiyama T, et al. Bioorg Med Chem. 2017 Apr 1;25(7):2234-2243. doi: 10.1016/j.bmc.2017.02.045. Epub 2017 Feb 27. Bioorg Med Chem. 2017. PMID: 28279560

4

Identification of a novel boronic acid as a potent, selective, and orally active hormone sensitive lipase inhibitor.

Ogiyama T, Yamaguchi M, Kurikawa N, Honzumi S, Yamamoto Y, Sugiyama D, Inoue S. Ogiyama T, et al. Bioorg Med Chem. 2016 Aug 15;24(16):3801-7. doi: 10.1016/j.bmc.2016.06.022. Epub 2016 Jun 11. Bioorg Med Chem. 2016. PMID: 27338659

5

Imaging of adeno-associated viral capsids for purposes of gene editing using CEST NMR/MRI.

Lam B, Velasquez M, Ogiyama T, Godines K, Szu FY, Velasquez-Mao AJ, AlGhuraibawi W, Wang J, Messersmith PB, Vandsburger MH. Lam B, et al. Among authors: ogiyama t. Magn Reson Med. 2024 Apr 23. doi: 10.1002/mrm.30058. Online ahead of print. Magn Reson Med. 2024. PMID: 38651648

6

Discovery of an 8-methoxytetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain without CYP inhibition liability.

Ogiyama T, Yonezawa K, Inoue M, Katayama N, Watanabe T, Yoshimura S, Gotoh T, Kiso T, Koakutsu A, Kakimoto S, Shishikura JI. Ogiyama T, et al. Bioorg Med Chem. 2015 Aug 1;23(15):4638-4648. doi: 10.1016/j.bmc.2015.05.053. Epub 2015 Jun 3. Bioorg Med Chem. 2015. PMID: 26078010

7

Discovery of a 1-isopropyltetrahydroisoquinoline derivative as an orally active N-type calcium channel blocker for neuropathic pain.

Ogiyama T, Yonezawa K, Inoue M, Watanabe T, Sugano Y, Gotoh T, Kiso T, Koakutsu A, Kakimoto S, Shishikura JI. Ogiyama T, et al. Bioorg Med Chem. 2015 Aug 1;23(15):4624-4637. doi: 10.1016/j.bmc.2015.05.030. Epub 2015 May 27. Bioorg Med Chem. 2015. PMID: 26071371

8

Discovery of novel tetrahydroisoquinoline derivatives as orally active N-type calcium channel blockers with high selectivity for hERG potassium channels.

Ogiyama T, Inoue M, Honda S, Yamada H, Watanabe T, Gotoh T, Kiso T, Koakutsu A, Kakimoto S, Shishikura J. Ogiyama T, et al. Bioorg Med Chem. 2014 Dec 15;22(24):6899-907. doi: 10.1016/j.bmc.2014.10.020. Epub 2014 Oct 22. Bioorg Med Chem. 2014. PMID: 25456079

9

Discovery of Ipragliflozin (ASP1941): a novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.

Imamura M, Nakanishi K, Suzuki T, Ikegai K, Shiraki R, Ogiyama T, Murakami T, Kurosaki E, Noda A, Kobayashi Y, Yokota M, Koide T, Kosakai K, Ohkura Y, Takeuchi M, Tomiyama H, Ohta M. Imamura M, et al. Among authors: ogiyama t. Bioorg Med Chem. 2012 May 15;20(10):3263-79. doi: 10.1016/j.bmc.2012.03.051. Epub 2012 Mar 29. Bioorg Med Chem. 2012. PMID: 22507206

10

Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors.

Nagashima S, Hondo T, Nagata H, Ogiyama T, Maeda J, Hoshii H, Kontani T, Kuromitsu S, Ohga K, Orita M, Ohno K, Moritomo A, Shiozuka K, Furutani M, Takeuchi M, Ohta M, Tsukamoto S. Nagashima S, et al. Among authors: ogiyama t. Bioorg Med Chem. 2009 Oct 1;17(19):6926-36. doi: 10.1016/j.bmc.2009.08.021. Epub 2009 Aug 15. Bioorg Med Chem. 2009. PMID: 19747833

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