Tang J - Search Results

1

Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase).

Ghosh AK, Shin D, Downs D, Koelsch G, Lin X, Ermolieff J, Tang J. Ghosh AK, et al. Among authors: tang j. J Am Chem Soc. 2000 Apr 12;122(14):3522-3523. doi: 10.1021/ja000300g. Epub 2000 Mar 23. J Am Chem Soc. 2000. PMID: 30443047 Free PMC article. No abstract available.

2

Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity.

Turner RT 3rd, Loy JA, Nguyen C, Devasamudram T, Ghosh AK, Koelsch G, Tang J. Turner RT 3rd, et al. Among authors: tang j. Biochemistry. 2002 Jul 9;41(27):8742-6. doi: 10.1021/bi025926t. Biochemistry. 2002. PMID: 12093293

3

Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.

He X, Chang WP, Koelsch G, Tang J. He X, et al. Among authors: tang j. FEBS Lett. 2002 Jul 31;524(1-3):183-7. doi: 10.1016/s0014-5793(02)03052-1. FEBS Lett. 2002. PMID: 12135764 Free article.

4

Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3.

Hong L, Turner RT 3rd, Koelsch G, Shin D, Ghosh AK, Tang J. Hong L, et al. Among authors: tang j. Biochemistry. 2002 Sep 10;41(36):10963-7. doi: 10.1021/bi026232n. Biochemistry. 2002. PMID: 12206667

5

Study of memapsin 2 (beta-secretase) and strategy of inhibitor design.

Tang J, Ghosh AK, Hong L, Koelsch G, Turner RT 3rd, Chang W. Tang J, et al. J Mol Neurosci. 2003;20(3):299-304. doi: 10.1385/JMN:20:3:299. J Mol Neurosci. 2003. PMID: 14501012 Review.

6

Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.

He X, Zhu G, Koelsch G, Rodgers KK, Zhang XC, Tang J. He X, et al. Among authors: tang j. Biochemistry. 2003 Oct 28;42(42):12174-80. doi: 10.1021/bi035199h. Biochemistry. 2003. PMID: 14567678

7

Memapsin 2, a drug target for Alzheimer's disease.

Koelsch G, Turner RT 3rd, Hong L, Ghosh AK, Tang J. Koelsch G, et al. Among authors: tang j. Biochem Soc Symp. 2003;(70):213-20. doi: 10.1042/bss0700213. Biochem Soc Symp. 2003. PMID: 14587294 Review.

8

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors.

Chang WP, Koelsch G, Wong S, Downs D, Da H, Weerasena V, Gordon B, Devasamudram T, Bilcer G, Ghosh AK, Tang J. Chang WP, et al. Among authors: tang j. J Neurochem. 2004 Jun;89(6):1409-16. doi: 10.1111/j.1471-4159.2004.02452.x. J Neurochem. 2004. PMID: 15189343 Free article.

9

Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein.

Huang XP, Chang WP, Koelsch G, Turner RT 3rd, Lupu F, Tang J. Huang XP, et al. Among authors: tang j. J Biol Chem. 2004 Sep 3;279(36):37886-94. doi: 10.1074/jbc.M402130200. Epub 2004 Jun 14. J Biol Chem. 2004. PMID: 15197182 Free article.

10

Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).

Ghosh AK, Devasamudram T, Hong L, DeZutter C, Xu X, Weerasena V, Koelsch G, Bilcer G, Tang J. Ghosh AK, et al. Among authors: tang j. Bioorg Med Chem Lett. 2005 Jan 3;15(1):15-20. doi: 10.1016/j.bmcl.2004.10.084. Bioorg Med Chem Lett. 2005. PMID: 15582402

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